The role of vascular adaptation in determining systolic BP in young adults
Cockcroft, John R.
MetadataShow full item record
Background: Two individuals can have a similar pulse pressure (PP) but very different levels of systolic blood pressure (SBP), although the underlying mechanisms have not been described. We hypothesised that, for a given level of PP, differences in SBP relate to peripheral vascular resistance (PVR) and we tested this hypothesis in a large cohort of healthy young adults. Methods and Results: Demographic, biochemical and haemodynamic data from 3103 subjects were available for the current analyses. In both males and females, for a given level of PP, higher SBP was associated with significantly higher body weight, body mass index, heart rate and PVR (P<0.05 versus those with lower BP for all comparisons). Moreover, stratifying individuals by quartiles of PP and PVR revealed a stepwise increase in SBP from the lowest to highest quartile for each variable, with the highest SBP occurring in those in the highest quartile of both PP and PVR (P<0.001 for overall trend for both sexes). PVR was also increased with increasing tertile of minimum forearm vascular resistance, in both males (P=0.002) and females (P=0.03). Conclusion: Increased PVR, mediated in part through altered resistance vessel structure, strongly associates with the elevation of SBP for a given level of PP in young adults. An impaired ability to adapt PVR appropriately to a given level of PP may be an important mechanism underlying elevated SBP in young adults.
Journal of the American Heart Association;
Yu, S., Middlemiss, J., Nardin, C., Hickson, S., Miles, K.,Yasmin, Maki-Petaja, K., McDonnell, B., Cockcroft, J., Wilkinson, I. and McEniery, C., 2019. The role of vascular adaptation in determining systolic BP in young adults. (in Press)
Article accepted for publication in Journal of the American Heart Association
British Heart Foundation (FS/06/005/20411)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Showing items related by title, author, subject and abstract.
Walters, Gareth (University of Wales, 2011)The aim of this analysis was to compare the differences and similarities between three different levels of rugby union (International, Regional and Semi Professional) in relation to the kicks used and their success. With ...
Turner, James (Cardiff Metropolitan University, 2013)Background: A lack of regular physical activity has become the fourth leading risk factor for global mortality today. Several physiological and psychological factors can decrease physical activity levels, such as age, ...
Jones, Liam (Cardiff Metropolitan University, 2011)Lipopolysaccaride (LPS) is one of the main components of the Gram negative cell wall, it gets released into the blood stream when bacterial cell are destroyed or lysed by the immune system. If the levels are allowed to ...