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dc.contributor.authorYu, Shikai
dc.contributor.authorMiddlemiss, Jessica
dc.contributor.authorNardin, Chiara
dc.contributor.authorHickson, Stacey
dc.contributor.authorMiles, Karen
dc.contributor.authorYasmin
dc.contributor.authorMaki-Petaja, Kaisa
dc.contributor.authorMcDonnell, Barry
dc.contributor.authorCockcroft, John R.
dc.contributor.authorWilkinson, Ian
dc.contributor.authorMcEniery, Carmel
dc.date.accessioned2020-03-05T11:57:31Z
dc.date.available2020-03-05T11:57:31Z
dc.date.issued2020-03-30
dc.identifier.citationYu, S., Middlemiss, J., Nardin, C., Hickson, S., Miles, K.,Yasmin, Maki-Petaja, K., McDonnell, B., Cockcroft, J., Wilkinson, I. and McEniery, C. (2020) 'Role of vascular adaptation in determining systolic BP in young adults', Journal of the American Heart Association, 9(7). DOI: 10.1161/JAHA.119.014375.en_US
dc.identifier.issn2047-9980
dc.identifier.urihttp://hdl.handle.net/10369/10959
dc.descriptionArticle published in Journal of the American Heart Association, available open access at: https://doi.org/10.1161/JAHA.119.014375.en_US
dc.description.abstractBackground: Two individuals can have a similar pulse pressure (PP) but very different levels of systolic blood pressure (SBP), although the underlying mechanisms have not been described. We hypothesised that, for a given level of PP, differences in SBP relate to peripheral vascular resistance (PVR) and we tested this hypothesis in a large cohort of healthy young adults. Methods and Results: Demographic, biochemical and haemodynamic data from 3103 subjects were available for the current analyses. In both males and females, for a given level of PP, higher SBP was associated with significantly higher body weight, body mass index, heart rate and PVR (P<0.05 versus those with lower BP for all comparisons). Moreover, stratifying individuals by quartiles of PP and PVR revealed a stepwise increase in SBP from the lowest to highest quartile for each variable, with the highest SBP occurring in those in the highest quartile of both PP and PVR (P<0.001 for overall trend for both sexes). PVR was also increased with increasing tertile of minimum forearm vascular resistance, in both males (P=0.002) and females (P=0.03). Conclusion: Increased PVR, mediated in part through altered resistance vessel structure, strongly associates with the elevation of SBP for a given level of PP in young adults. An impaired ability to adapt PVR appropriately to a given level of PP may be an important mechanism underlying elevated SBP in young adults.en_US
dc.description.sponsorshipBritish Heart Foundation (FS/06/005/20411)en_US
dc.description.sponsorshipCambridge University Hospitals NHS Foundation Trust (CUH) (146281)en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesJournal of the American Heart Association;
dc.titleRole of vascular adaptation in determining systolic BP in young adultsen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1161/JAHA.119.014375
dcterms.dateAccepted2020-02-27
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en_US


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