“Bionic Women and Men” Part 1: Cardiovascular Lessons from Heart Failure Patients Implanted with Left Ventricular Assist Devices (LVADs)
Stöhr, Eric J.
Cornwell III, William
Cockcroft, John R.
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Some humans with chronic, advanced heart failure are surgically implanted with a left ventricular assist device (LVAD). Because the LVAD produces a continuous flow, a palpable pulse is often absent in these patients. This allows for a unique investigation of the human circulation and has created a controversy around the ‘need’ for a pulse. The medical debate has also generated a more generic, fundamental discussion into what is ‘normal’ arterial physiology and health. The comprehensive study and understanding of the arterial responses to drastically altered haemodynamics due to continuous‐flow LVADs, at rest and during activity, presents an opportunity to significantly increase our current understanding of the fundamental components of arterial regulation (flow, blood pressure, sympathetic activity, endothelial function, pulsatility) in a way that could never have been studied previously. In a series of four articles, we summarize the talks presented at the symposium entitled ‘Bionic women and men – Physiology lessons from implantable cardiac devices’ presented at the 2019 Annual Meeting of The Physiological Society in Aberdeen, UK. The articles highlight the novel questions generated by physiological phenomena observed in LVAD patients and propose future areas of interest within the field of cardiovascular physiology.
Stöhr, E.J., Cornwell, W., Kanwar, M., Cockcroft, J.R. and McDonnell, B.J. (2020) 'Bionic women and men part 1–Cardiovascular lessons from heart failure patients implanted with left ventricular assist devices (LVADs)'. Experimental Physiology. DOI: 10.1113/EP088323.
Article published in Experimental Physiology on 27 February, available open access at: https://doi.org/10.1113/EP088323.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
B.J.M. and E.J.S. received funding from the European Union's Horizon 2020. Their project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska‐Curie grant agreement no. 705219. W.K.C. has received funding by an NIH/NHLBI Mentored Patient‐33 Oriented Research Career Development Award (No. 1K23HLI32048‐01), as well as the 34 NIH/NCATS (No. UL1TR002535), Susie and Kurt Lochmiller Distinguished Heart Transplant 35 Fund, the Clinical Translational Science Institute at the University of Colorado Anschutz 36 Medical Campus, and Medtronic Inc.
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