“Bionic Women and Men” Part 2: Arterial Stiffness in Heart Failure Patients Implanted with Left Ventricular Assist Devices (LVADs)
Cornwell III, William
Cockcroft, John R.
Stöhr, Eric J.
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In parallel with the major advances in clinical care, technological advancements and implantation of mechanical circulatory support in patients with severe heart failure have resulted in these patients living longer. However, these patients are still at increased risk of stroke and gastrointestinal bleeding. The unique continuous flow produced by various left ventricular assist devices (LVAD) has been suggested as one potential reason for this increased risk of stroke and GI bleeding. Furthermore, these continuous‐flow (CF) devices challenge our understanding of circulatory blood pressure and flow regulation in relation to organ health. In healthy pulsatile and dynamic systems, arterial stiffness is a major independent risk factor for stroke. However, to date, there are limited data regarding the impact of CF‐LVAD therapy on arterial stiffness. The purpose of this report is to discuss the varied impact of CF‐LVAD therapy on arterial stiffness and attempt to highlight some potential mechanisms linking these associations in this unique population.
McDonnell, B.J., Rosenblum, H., Cornwell, W., Kanwar, M., Cockcroft, J.R. and Stöhr, E.J. (2020) '“Bionic Women and Men”‐Part 2: Arterial Stiffness in Heart Failure Patients Implanted with Left Ventricular Assist Devices (LVADs)', Experimental Physiology. DOI: 10.1113/EP088326.
Article published in Experimental Physiology on 7 March 2020, available open access at: https://doi.org/10.1113/EP088326.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Drs Stohr and McDonnell have received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 705219. Dr. Cornwell has received funding by an NIH/NHLBI Mentored Patient-33 Oriented Research Career Development Award (#1K23HLI32048-01), as well as the 34 NIH/NCATS (#UL1TR002535), Susie and Kurt Lochmiller Distinguished Heart Transplant 35 Fund, the Clinical Translational Science Institute at the University of Colorado Anschutz 36 Medical Campus, and Medtronic Inc. Dr Kanwar has received Research funding by Abbott Inc. but none relevant to this submission.
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