“Bionic Women and Men” Part 3: Right ventricular dysfunction in patients implanted with left ventricular assist devices
Cockcroft, John R.
Stöhr, Eric J.
Cornwell III, William
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The adaptation of the right ventricular (RV) output to a left ventricular assist device (LVAD) often determines the fate of patients with pulmonary hypertension secondary to left heart failure. Pre‐existing right heart dysfunction in patients with advanced left heart failure is the consequence of increased (arterial) afterload and not simply the consequence of myocardial disease. If unaccounted for, it has the potential of accelerating into clinical right heart failure after LVAD, leading to significant morbidity and mortality. After LVAD implantation, the RV has to face increased flow generated by the LVAD, cardiac arrhythmias and exaggerated functional interactions between both ventricles. Understanding the key physiological mechanisms of RV dysfunction in patients with end‐stage heart failure will allow us to predict and therefore prevent RV failure after LVAD implantation.
Kanwar, M., McDonnell, B.J., Rosenblum, H., Cockcroft, J.R., Stöhr, E.J. and Cornwell, W. (2020) 'Right ventricular dysfunction in patients implanted with left ventricular assist devices', Experimental Physiology. DOI: 10.1113/EP088324.
Article published in Experimental Physiology on 27 February 2020, available at: https://doi.org/10.1113/EP088324.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Dr Kanwar has received research funding by Abbott Inc. but none relevant to this submission. Drs McDonnell and Stohr have received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 705219. Dr. Cornwell has received funding by an NIH/NHLBI Mentored Patient-33 Oriented Research Career Development Award (#1K23HLI32048-01), as well as the 34 NIH/NCATS (#UL1TR002535), Susie and Kurt Lochmiller Distinguished Heart Transplant 35 Fund, the Clinical Translational Science Institute at the University of Colorado Anschutz 36 Medical Campus, and Medtronic Inc.
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