“Bionic Women and Men” Part 4: Cardiovascular, Cerebrovascular and Exercise Responses Among Patients Supported with Left Ventricular Assist Devices
Cockcroft, John R.
Stöhr, Eric J.
Cornwell III, William
MetadataShow full item record
Current generation left ventricular assist devices (LVADs) have led to significant improvements in survival compared to medical therapy alone, when used for management of patients with advanced heart failure. However, there are a number of side-effects associated with LVAD use, including hypertension, gastrointestinal bleeding, stroke, as well as persistent and severe limitations in functional capacity despite normalization of a resting cardiac output (Qc). These issues are, in large part, related to chronic exposure to a non-physiologic pulse, which contributes to a hyperadrenergic environment characterized by markedly elevated levels of sympathetic nerve activity through a baroreceptor-mediated pathway. In addition, these machines are unable to participate in, or contribute to, normal cardiovascular/autonomic reflexes that attempt to modulate flow through the body. Efforts to advance device technology and develop biologically sensitive devices may resolve these issues, and lead to further improvements in quality-of-life, functional capacity, and ultimately, survival, for the patients they support.
Buchanan, C., Kanwar, M., Cockcroft, J.R., McDonnell, B., Stöhr, E.J. and Cornwell III, W.K. (2020) 'Bionic women and men part 4–cardiovascular, cerebrovascular and exercise responses among patients supported with left ventricular assist devices', Experimental Physiology. DOI: 10.1113/EP088325.
Article published in Experimental Physiology on 27 February 2020, available at: https://doi.org/10.1113/EP088325.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Drs McDonnell and Stohr have received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 705219. Dr. Cornwell has received funding by an NIH/NHLBI Mentored Patient-Oriented Research Career Development Award (#1K23HLI32048-01), as well as the NIH/NCATS (#UL1TR002535), Susie and Kurt Lochmiller Distinguished Heart Transplant Fund, the Clinical Translational Science Institute at the University of Colorado Anschutz Medical Campus, and Medtronic Inc. Dr. Kanwar has received research funding by Abbott Inc, but none relevant to this submission.
- Sport Research Groups