Show simple item record

dc.contributor.authorBuchanan, Cullen
dc.contributor.authorKanwar, Manreet
dc.contributor.authorCockcroft, John R.
dc.contributor.authorMcDonnell, Barry
dc.contributor.authorStöhr, Eric J.
dc.contributor.authorCornwell III, William
dc.date.accessioned2020-04-06T11:58:02Z
dc.date.available2020-04-06T11:58:02Z
dc.date.issued2020-02-27
dc.identifier.citationBuchanan, C., Kanwar, M., Cockcroft, J.R., McDonnell, B., Stöhr, E.J. and Cornwell III, W.K. (2020) 'Bionic women and men part 4–cardiovascular, cerebrovascular and exercise responses among patients supported with left ventricular assist devices', Experimental Physiology. DOI: 10.1113/EP088325.en_US
dc.identifier.issn1469-445X
dc.identifier.urihttp://hdl.handle.net/10369/10989
dc.descriptionArticle published in Experimental Physiology on 27 February 2020, available at: https://doi.org/10.1113/EP088325.en_US
dc.description.abstractCurrent generation left ventricular assist devices (LVADs) have led to significant improvements in survival compared to medical therapy alone, when used for management of patients with advanced heart failure. However, there are a number of side-effects associated with LVAD use, including hypertension, gastrointestinal bleeding, stroke, as well as persistent and severe limitations in functional capacity despite normalization of a resting cardiac output (Qc). These issues are, in large part, related to chronic exposure to a non-physiologic pulse, which contributes to a hyperadrenergic environment characterized by markedly elevated levels of sympathetic nerve activity through a baroreceptor-mediated pathway. In addition, these machines are unable to participate in, or contribute to, normal cardiovascular/autonomic reflexes that attempt to modulate flow through the body. Efforts to advance device technology and develop biologically sensitive devices may resolve these issues, and lead to further improvements in quality-of-life, functional capacity, and ultimately, survival, for the patients they support.en_US
dc.description.sponsorshipDrs McDonnell and Stohr have received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 705219. Dr. Cornwell has received funding by an NIH/NHLBI Mentored Patient-Oriented Research Career Development Award (#1K23HLI32048-01), as well as the NIH/NCATS (#UL1TR002535), Susie and Kurt Lochmiller Distinguished Heart Transplant Fund, the Clinical Translational Science Institute at the University of Colorado Anschutz Medical Campus, and Medtronic Inc. Dr. Kanwar has received research funding by Abbott Inc, but none relevant to this submission.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesExperimental Physiology;
dc.title“Bionic Women and Men” Part 4: Cardiovascular, Cerebrovascular and Exercise Responses Among Patients Supported with Left Ventricular Assist Devicesen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1113/EP088325
dcterms.dateAccepted2020-02-26
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2020-04-06
rioxxterms.freetoread.startdate2021-02-27
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record