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dc.contributor.authorHeymans, C.
dc.contributor.authorHeij, L.
dc.contributor.authorLenaerts, K.
dc.contributor.authorden Dulk, M.
dc.contributor.authorHadfoune, M.
dc.contributor.authorvan Heugten, C.
dc.contributor.authorSpiller, O.B.
dc.contributor.authorBeeton, Michael L.
dc.date.accessioned2020-06-05T09:22:35Z
dc.date.available2020-06-05T09:22:35Z
dc.date.issued2020-05-05
dc.identifier.citationHeymans, C., Heij, L.R., Lenaerts, K., den Dulk, M., Hadfoune, M., van Heugten, C., Spiller, O.B., Beeton, M.L., Stock, S.J., Jobe, A.H. and Payne, M.S. (2020) 'Prophylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine Ureaplasma parvum Infection Partly Prevents Liver Inflammation without Interfering with the Enterohepatic Circulation of the Fetal Sheep', Nutrients, 12(5), p.1312.en_US
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10369/11054
dc.descriptionArticle published in Nutrients on 5 May 2020, available open access at: https://doi.org/10.3390/nu12051312.en_US
dc.description.abstractChorioamnionitis can lead to inflammation and injury of the liver and gut, thereby predisposing patients to adverse outcomes such as necrotizing enterocolitis (NEC). In addition, intestinal bile acids (BAs) accumulation is causally linked to NEC development. Plant sterols are a promising intervention to prevent NEC development, considering their anti-inflammatory properties in the liver. Therefore, we investigated whether an intra-amniotic (IA) Ureaplasma parvum (UP) infection affected the liver and enterohepatic circulation (EHC) and evaluated whether an IA administered plant sterol mixture dissolved in β-cyclodextrin exerted prophylactic effects. An ovine chorioamnionitis model was used in which liver inflammation and the EHC were assessed following IA UP exposure in the presence or absence of IA prophylactic plant sterols (a mixture of β-sitosterol and campesterol dissolved in β-cyclodextrin (carrier)) or carrier alone. IA UP exposure caused an inflammatory reaction in the liver, histologically seen as clustered and conflated hepatic erythropoiesis in the parenchyma, which was partially prevented by IA administration of sterol + β-cyclodextrin, or β-cyclodextrin alone. In addition, IA administration of β-cyclodextrin prior to UP caused changes in the expression of several hepatic BAs transporters, without causing alterations in other aspects of the EHC. Thereby, the addition of plant sterols to the carrier β-cyclodextrin did not have additional effects.en_US
dc.description.sponsorshipThis work was financially supported by Kinderonderzoekfonds Limburg (Health Foundation Limburg) (T.G.A.M.W.).en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofseriesNutrients;
dc.titleProphylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine Ureaplasma parvum Infection Partly Prevents Liver Inflammation without Interfering with the Enterohepatic Circulation of the Fetal Sheepen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3390/nu12051312
dcterms.dateAccepted2020-04-29
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2020-06-05
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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