• English
    • Welsh
  • English 
    • English
    • Welsh
  • Login
Search DSpace:
  • Home
  • Research at Cardiff Met
  • Library Services
  • Contact Us
View item 
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Cardiovascular Health and Ageing
  • View item
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Cardiovascular Health and Ageing
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Extracellular Vesicles in the Synovial Joint: Is There a Role in the Pathophysiology of Osteoarthritis?

Thumbnail
Author
Esa, A.
Connolly, Katherine D.
Williams, R.
Archer, C.W.
Date
2019-03-01
Acceptance date
2019-02-17
Type
Article
Publisher
University of Malaya
ISSN
2232-111X
Metadata
Show full item record
Abstract
The role of extracellular vesicles (EV) in osteoarthritis has become the focus of much research. These vesicles were isolated from several cell types found in synovial joint including chondrocytes and synovium. As articular cartilage is an avascular tissue surrounded by synovial fluid, it is believed that EV might play a crucial role in the homeostasis of cartilage and also could hold key information in the pathogenesis of osteoarthritis. This is thought to be due to activation of pro-inflammatory factors leading to a catabolic state and degradation of cartilage. In addition, due to the nature of articular cartilage lacking neuronal innervation, knowledge of EV can contribute to identification of novel biomarkers in this debilitating condition. This can be either directly isolated from aspirate of synovial fluid or from peripheral blood. Finally, EVs are known to shuttle important signalling molecules which can be utilised as unique modality in transferring therapeutic compounds in a cell free manner.
Journal/conference proceeding
Malaysian Orthopaedic Journal;
Citation
Esa, A., Connolly, K.D., Williams, R. and Archer, C.W. (2019) 'Extracellular Vesicles in the Synovial Joint: Is there a Role in the Pathophysiology of Osteoarthritis?', Malaysian Orthopaedic Journal, 13(1), p.1.
URI
http://hdl.handle.net/10369/11062
DOI
http://dx.doi.org/10.5704/MOJ.1903.012
Description
Article published in Malaysian Orthopaedic Journal in March 2019, available open access at: http://dx.doi.org/10.5704/MOJ.1903.012.
Rights
http://creativecommons.org/licenses/by/4.0/
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Collections
  • Cardiovascular Health and Ageing [156]

Browse

DSpace at Cardiff MetCommunities & CollectionsBy issue dateAuthorsTitlesSubjectsThis collectionBy issue dateAuthorsTitlesSubjects

My Account

Login

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Contact us | Send feedback | Administrator