Extracellular Vesicles in the Synovial Joint: Is There a Role in the Pathophysiology of Osteoarthritis?
Connolly, Katherine D.
University of Malaya
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The role of extracellular vesicles (EV) in osteoarthritis has become the focus of much research. These vesicles were isolated from several cell types found in synovial joint including chondrocytes and synovium. As articular cartilage is an avascular tissue surrounded by synovial fluid, it is believed that EV might play a crucial role in the homeostasis of cartilage and also could hold key information in the pathogenesis of osteoarthritis. This is thought to be due to activation of pro-inflammatory factors leading to a catabolic state and degradation of cartilage. In addition, due to the nature of articular cartilage lacking neuronal innervation, knowledge of EV can contribute to identification of novel biomarkers in this debilitating condition. This can be either directly isolated from aspirate of synovial fluid or from peripheral blood. Finally, EVs are known to shuttle important signalling molecules which can be utilised as unique modality in transferring therapeutic compounds in a cell free manner.
Malaysian Orthopaedic Journal;
Esa, A., Connolly, K.D., Williams, R. and Archer, C.W. (2019) 'Extracellular Vesicles in the Synovial Joint: Is there a Role in the Pathophysiology of Osteoarthritis?', Malaysian Orthopaedic Journal, 13(1), p.1.
Article published in Malaysian Orthopaedic Journal in March 2019, available open access at: http://dx.doi.org/10.5704/MOJ.1903.012.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))