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dc.contributor.authorEsa, A.
dc.contributor.authorConnolly, Katherine D.
dc.contributor.authorWilliams, R.
dc.contributor.authorArcher, C.W.
dc.date.accessioned2020-06-11T09:36:08Z
dc.date.available2020-06-11T09:36:08Z
dc.date.issued2019-03-01
dc.identifier.citationEsa, A., Connolly, K.D., Williams, R. and Archer, C.W. (2019) 'Extracellular Vesicles in the Synovial Joint: Is there a Role in the Pathophysiology of Osteoarthritis?', Malaysian Orthopaedic Journal, 13(1), p.1.en_US
dc.identifier.issn2232-111X
dc.identifier.urihttp://hdl.handle.net/10369/11062
dc.descriptionArticle published in Malaysian Orthopaedic Journal in March 2019, available open access at: http://dx.doi.org/10.5704/MOJ.1903.012.en_US
dc.description.abstractThe role of extracellular vesicles (EV) in osteoarthritis has become the focus of much research. These vesicles were isolated from several cell types found in synovial joint including chondrocytes and synovium. As articular cartilage is an avascular tissue surrounded by synovial fluid, it is believed that EV might play a crucial role in the homeostasis of cartilage and also could hold key information in the pathogenesis of osteoarthritis. This is thought to be due to activation of pro-inflammatory factors leading to a catabolic state and degradation of cartilage. In addition, due to the nature of articular cartilage lacking neuronal innervation, knowledge of EV can contribute to identification of novel biomarkers in this debilitating condition. This can be either directly isolated from aspirate of synovial fluid or from peripheral blood. Finally, EVs are known to shuttle important signalling molecules which can be utilised as unique modality in transferring therapeutic compounds in a cell free manner.en_US
dc.language.isoenen_US
dc.publisherUniversity of Malayaen_US
dc.relation.ispartofseriesMalaysian Orthopaedic Journal;
dc.titleExtracellular Vesicles in the Synovial Joint: Is There a Role in the Pathophysiology of Osteoarthritis?en_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.5704/MOJ.1903.012
dcterms.dateAccepted2019-02-17
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionNAen_US
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2020-06-11
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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