The influence of habitual endurance exercise on carotid artery strain and strain-rate in young and middle-aged men
Pugh, Christopher J. A.
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Central arterial stiffness is an independent predictor of cardiovascular risk that can be modified by exercise training. However, conventional local measures of carotid artery stiffness display conflicting responses to habitual endurance exercise in young and older adults. 2D-Strain imaging of the common carotid artery (CCA) quantifies circumferential deformation (strain) of the arterial wall across the cardiac cycle, which is more sensitive at detecting age-related alterations in CCA stiffness than conventional methods. Therefore, the study was designed to examine the relationship between habitual endurance exercise (running) and CCA 2D-Strain parameters in young and middle-aged men. Short-axis ultrasound images of the CCA were obtained from 13 young nonrunners (23 years [95% CI: 21-26]), 19 young runners (24 [22-26]), 13 middle-aged nonrunners (54 [52-56]) and 19 middle-aged runners (56 [54-58]). Images were analysed for peak circumferential strain (PCS; magnitude of deformation) as well as systolic and diastolic strain-rate (S-SR and D-SR; deformation velocity) and group differences were examined via two-way ANOVA. PCS, S-SR and D-SR were attenuated in middle-aged males when compared to young men (all P ≤ 0.001). PCS and S-SR were elevated in young and middle-aged runners when compared to nonrunners (P = 0.002 and P =0.009 respectively), but no age*training status interaction was observed. In contrast, there was no influence of habitual running on D-SR. Habitual exercise is associated with comparable improvements in CCA 2D-Strain parameters in young and middle-aged men, but the age-related decline in PCS and S-SR may be more amenable to habitual endurance exercise than D-SR.
Talbot, J.S., Lord, R.N., Wakeham, D.J., Dawkins, T.G., Curry, B.A., Brown, M., Lodge, F.M. and Pugh, C.J. (2020) 'The influence of habitual endurance exercise on carotid artery strain and strain‐rate in young and middle‐aged men', Experimental Physiology. https://doi.org/10.1113/EP088384
Article published in Experimental Physiology on 24 June 2020, available at: https://doi.org/10.1113/EP088384.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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