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dc.contributor.authorWatanabe, Kazuhito
dc.contributor.authorStöhr, Eric J.
dc.contributor.authorAkiyama, Koichi
dc.contributor.authorWatanabe, Sumie
dc.contributor.authorGonzalez-Alonso, Jose
dc.date.accessioned2020-06-25T10:54:40Z
dc.date.available2020-06-25T10:54:40Z
dc.date.issued2020-06-15
dc.identifier.citationWatanabe, K., Stöhr, E.J., Akiyama, K., Watanabe, S. and González‐Alonso, J. (2020) 'Dehydration reduces stroke volume and cardiac output during exercise because of impaired cardiac filling and venous return, not left ventricular function', Physiological Reports, 8(11), p.e14433.en_US
dc.identifier.issn2051-817X
dc.identifier.urihttp://hdl.handle.net/10369/11079
dc.descriptionArticle published in Physiological Reports on 15 June 2020, available open access at: https://doi.org/10.14814/phy2.14433.en_US
dc.description.abstractDehydration accrued during intense prolonged whole‐body exercise in the heat compromises peripheral blood flow and cardiac output (Q). A markedly reduced stroke volume (SV) is a key feature of the dehydration‐induced cardiovascular strain, but whether the lower output of the heart is mediated by peripheral or cardiac factors remains unknown. Therefore, we repeatedly quantified left ventricular (LV) volumes, LV mechanics (LV twist, a marker of systolic muscle function, and LV untwisting rate, an independent marker of LV muscle relaxation), left intra‐ventricular pressure gradients, blood volume and peripheral blood flow during 2 hr of cycling in the heat with and without dehydration (DEH: 4.0 ± 0.2% body mass loss and EUH: euhydration control, respectively) in eight participants (three females and five males). While brachial and carotid blood flow, blood volume, SV, LV end‐diastolic volume (LVEDV), cardiac filling time, systemic vascular conductance and Q were reduced in DEH compared to EUH after 2 hr, LV twist and untwisting rate tended to be higher (p = .09 and .06, respectively) and intra‐ventricular pressure gradients were not different between the two conditions (p = .22). Furthermore, LVEDV in DEH correlated strongly with blood volume (r = .995, p < .01), head and forearms beat volume (r = .98, p < .05), and diastolic LV filling time (r = .98, p < .05). These findings suggest that the decline in SV underpinning the blunted Q with exercise‐induced dehydration is caused by compromised LV filling and venous return, but not intrinsic systolic or diastolic LV function.en_US
dc.description.sponsorshipMinistry of Education, Culture, Sports, Science and Technology of Japan. Grant Numbers: 15J00841, 19K20034en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesPhysiological Reports;
dc.titleDehydration reduces stroke volume and cardiac output during exercise because of impaired cardiac filling and venous return, not left ventricular functionen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.14814/phy2.14433
dcterms.dateAccepted2020-04-12
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2020-06-25
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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