Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss

View/ open
Author
Cai, Yuexin
Xie, Mingwei
Su, Yun
Tong, Zhaopeng
Wu, Xiaoyan
Xu, Wenchao
Li, Jiahong
Zhao, Fei
Dang, Caiping
Chen, Guisheng
Lan, Liping
Shen, Jun
Zheng, Yiqing
Date
2020-06-30Acceptance date
2020-05-14
Type
Article
Publisher
Frontiers Media
ISSN
1662-4548
1662-453X (online)
Metadata
Show full item recordAbstract
Purpose: The neural bases in acute tinnitus remains largely undetected. The objective of this study was to identify the alteration of the brain network involved in patients with acute tinnitus and hearing loss.
Methods: Acute tinnitus patients (n = 24) with hearing loss and age-, sex-, education-matched healthy controls (n = 21) participated in the current study and underwent resting-state functional magnetic resonance imaging (fMRI) scanning. Regional homogeneity and amplitude of low-frequency fluctuation were used to investigate the local spontaneous neural activity and functional connectivity (FC), and Granger causality analysis (GCA) was used to analyze the undirected and directed connectivity of brain regions.
Results: Compared with healthy subjects, acute tinnitus patients had a general reduction in FC between auditory and non-auditory brain regions. Based on FC analysis, the superior temporal gyrus (STG) revealed reduced undirected connectivity with non-auditory brain regions including the amygdala (AMYG), nucleus accumbens (NAc), the cerebellum, and postcentral gyrus (PoCG). Using the GCA algorithm, increased effective connectivity from the right AMYG to the right STG, and reduced connectivity from the right PoCG to the left NAc was observed in acute tinnitus patients with hearing loss. The pure-tone threshold was positively correlated with FC between the AMYG and STG, and negatively correlated with FC between the left NAc and the right PoCG. In addition, a negative association between the GCA value from the right PoCG to the left NAc and the THI scores was observed.
Conclusion: Acute tinnitus patients have aberrant FC strength and causal connectivity in both the auditory and non-auditory cortex, especially in the STG, AMYG, and NAc. The current findings will provide a new perspective for understanding the neuropathophysiological mechanism in acute tinnitus.
Journal/conference proceeding
Frontiers in Neuroscience;
Citation
Cai, Y., Xie, M., Wu, X., Tong, Z., Su, Y., Xu, W., Li, J., Zhao, F., Dang, C., Chen, G. and Lan, L. (2020) 'Aberrant Functional and Causal Connectivity in Acute Tinnitus with Sensorineural Hearing Loss', Frontiers in Neuroscience, 14. https://doi.org/10.3389/fnins.2020.00592
Description
Article published in Frontiers in Neuroscience available open access at https://doi.org/10.3389/fnins.2020.00592
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Collections
Related items
Showing items related by title, author, subject and abstract.
-
Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus
Lan, Liping; Li, Jiahong; Chen, Yanhong; Chen, Wan; Li, Wenrui; Zhao, Fei; Chen, Guisheng; Liu, Jiahao; Chen, Yuchen; Li, Yuanqing; Wang, Chang-Dong; Zheng, Yiqing; Cai, Yuexin (Wiley, 2020-10-13)The objective of this study was to investigate alterations to brain activity and functional connectivity in patients with tinnitus, exploring neural features in the transition from acute to chronic phantom perception. ... -
Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEG
Cai, Y.; Li, J.; Chen, Y.; Chen, W.; Dang, C.; Zhao, Fei; Li, W.; Chen, G.; Chen, S.; Liang, M.; Zheng, Y. (Frontiers Media, 2019-08-14)This study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. ... -
Auditory spatial discrimination and the mismatch negativity response in hearing-impaired individuals
Cai, Yuexin; Zheng, Yiqing; Liang, Maojin; Zhao, Fei; Yu, Guangzheng; Liu, Yu; Chen, Yeubo; Chen, Guisheng (Public Library of Science, 2015)The aims of the present study were to investigate the ability of hearing-impaired (HI) individuals with different binaural hearing conditions to discriminate spatial auditory-sources at the midline and lateral positions, ...