Show simple item record

dc.contributor.authorLord, Rachel
dc.contributor.authorWakeham, Denis
dc.contributor.authorPugh, Christopher J. A.
dc.contributor.authorSimpson, Lydia
dc.contributor.authorTalbot, Jack
dc.contributor.authorLodge, Freya
dc.contributor.authorCurry, Bryony
dc.contributor.authorDawkins, Tony
dc.contributor.authorShave, Rob
dc.contributor.authorMoore, Jonathan
dc.date.accessioned2020-07-03T09:50:32Z
dc.date.available2020-07-03T09:50:32Z
dc.date.issued2020-08-01
dc.identifierhttps://repository.cardiffmet.ac.uk/bitstream/id/46028/AJP%20heart%20and%20circ%20FINALV2.pdf
dc.identifierhttps://repository.cardiffmet.ac.uk/bitstream/id/46028/AJP%20heart%20and%20circ%20FINALV2.pdf
dc.identifier.citationLord, R.N., Wakeham, D.J., Pugh, C.J., Simpson, L.L., Talbot, J.S., Lodge, F.M., Curry, B.A., Dawkins, T.G., Shave, R.E. and Moore, J.P., (2020) 'The influence of barosensory vessel mechanics on the vascular sympathetic baroreflex: insights into ageing and blood pressure homeostasis', American Journal of Physiology-Heart and Circulatory Physiology.
dc.identifier.issn0363-6135
dc.identifier.issn1522-1539 (online)
dc.identifier.urihttp://hdl.handle.net/10369/11092
dc.descriptionArticle published in American Journal of Physiology - Heart and Circulatory Physiology on 10 July 2020, available at: https://doi.org/10.1152/ajpheart.00265.2020.en_US
dc.description.abstractChanges in the arterial baroreflex arc contribute to elevated sympathetic outflow and altered reflex control of blood pressure with human ageing. Utilizing ultrasound and sympathetic microneurography (muscle sympathetic nerve activity; MSNA) we investigated the relationships between aortic and carotid artery wall tension (indices of baroreceptor activation) and the vascular sympathetic baroreflex operating point (OP; MSNA burst incidence) in healthy, normotensive young (n = 27, 23 ± 3 years) and middle-aged men (n = 22, 55 ± 4 years). In young men, the OP was positively related to the magnitude and rate of unloading and time spent unloaded in the aortic artery (r = 0.56, 0.65 and 0.51, P = 0.02, 0.003 and 0.03), but not related to the magnitude or rate of unloading or time spent unloaded in the carotid artery (r = -0.32, -0.07 and 0.06, P = 0.25, 0.81 and 0.85). In contrast, in middle-aged men, the OP was not related to either the magnitude or rate of unloading or time spent unloaded in the aortic (r = 0.22, 0.21 and 0.27, P = 0.41, 0.43 and 031) or carotid artery (r = 0.48, 0.28 and -0.01, P = 0.06, 0.25 and 0.98). In conclusion, in young men, aortic unloading mechanics may play a role in determining the vascular sympathetic baroreflex OP. In contrast, in middle-aged men, barosensory vessel unloading mechanics do not appear to determine the vascular sympathetic baroreflex OP, and therefore do not contribute to age-related arterial baroreflex resetting and increased resting MSNA. KEYWORDS: muscle sympathetic nerve activity; barosensory vessel unloading mechanics; healthy ageing; sympathetic nervous system; baroreflex Page Break NEW AND NOTEWORTHY We assessed the influence of barosensory vessel mechanics (magnitude and rate of unloading and time spent unloaded) as a surrogate for baroreceptor unloading. In young men, aortic unloading mechanics are important in regulating the operating point of the vascular sympathetic baroreflex, whereas in middle-aged men, these arterial mechanics do not influence this operating point. The age-related increase in resting muscle sympathetic nerve activity does not appear to be driven by altered baroreceptor input from stiffer barosensory vessels.en_US
dc.language.isoenen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.ispartofseriesAmerican Journal of Physiology - Heart and Circulatory Physiology;
dc.titleThe influence of barosensory vessel mechanics on the vascular sympathetic baroreflex: Insights into ageing and blood pressure homeostasisen_US
dc.typeArticleen_US
dc.typeacceptedVersion
dcterms.dateAccepted2020-07-02
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecordhttps://doi.org/10.1152/ajpheart.00265.2020
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.publicationdate2020-08-01
dc.date.refFCD2020-07-03
rioxxterms.freetoread.startdate2021-07-10
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record