Stimulus-specific functional remodeling of the left ventricle in endurance and resistance-trained men
Drane, Aimee L.
Pugh, Christopher J. A.
American Physiological Society
MetadataShow full item record
Left ventricular (LV) structural remodeling following athletic training has been evidenced through training-specific changes in wall thickness and geometry. Whether the LV response to changes in hemodynamic load also adapts in a training-specific manner is unknown. Using echocardiography, we examined LV responses of endurance-trained (n = 15), resistance-trained (n = 14), and nonathletic men (n = 13) to 1) 20, 40, and 60% one repetition-maximum (1RM), leg-press exercise and 2) intravascular Gelofusine infusion (7 mL/kg) with passive leg raise. While resting heart rate was lower in endurance-trained participants versus controls (P = 0.001), blood pressure was similar between groups. Endurance-trained individuals had lower wall thickness but greater LV mass relative to body surface area versus controls, with no difference between resistance-trained individuals and controls. Leg press evoked a similar increase in blood pressure; however, resistance-trained participants preserved stroke volume (SV; −3 ± 8%) versus controls at 60% 1RM (−15 ± 7%, P = 0.001). While the maintenance of SV was related to the change in longitudinal strain across all groups (R = 0.537; P = 0.007), time-to-peak strain was maintained in resistance-trained but delayed in endurance-trained individuals (1 vs. 12% delay; P = 0.021). Volume infusion caused a similar increase in end-diastolic volume (EDV) and SV across groups, but leg raise further increased EDV only in endurance-trained individuals (5 ± 5 to 8 ± 5%; P = 0.018). Correlation analysis revealed a relationship between SV and longitudinal strain following infusion and leg raise (R = 0.334, P = 0.054); however, we observed no between-group differences in longitudinal myocardial mechanics. In conclusion, resistance-trained individuals better maintained SV during pressure loading, whereas endurance-trained individuals demonstrated greater EDV reserve during volume loading. These data provide novel evidence of training-specific LV functional remodeling. NEW & NOTEWORTHY Training-specific functional remodeling of the LV in response to different loading conditions has been recently suggested, but not experimentally tested in the same group of individuals. Our data provide novel evidence of a dichotomous, training-specific LV adaptive response to hemodynamic pressure or volume loading.
American Journal of Physiology - Heart and Circulatory Physiology;
Dawkins, T.G., Curry, B.A., Drane, A.L., Lord, R.N., Richards, C., Brown, M., Pugh, C.J., Lodge, F., Yousef, Z., Stembridge, M. and Shave, R.E. (2020) 'Stimulus-specific functional remodeling of the left ventricle in endurance and resistance-trained men', American Journal of Physiology-Heart and Circulatory Physiology, 319(3), pp.H632-H641.
Article published in American Journal of Physiology-Heart and Circulatory Physiology available at https://doi.org/10.1152/ajpheart.00233.2020
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
- Sport Research Groups 
Showing items related by title, author, subject and abstract.
Utomi, Victor; Oxborough, David; Ashely, Evan; Lord, Rachel; Fletcher, Sarah; Stembridge, Mike; Shave, Rob; Hoffman, Martin; Whyte, Greg; Somauroo, John; Sharma, Sanjay; George, Keith (BMJ, 2014-06-10)Aims = This study evaluated (a) global LV adaption to endurance versus resistance training in male athletes, (b) LV assessment using by modern imaging technologies and (c) the impact of scaling for body size on LV structural ...
The impact of chronic endurance and resistance training upon the right ventricular phenotype in male athletes Utomi, Victor; Oxborough, David; Ashely, Euan; Lord, Rachel; Fletcher, Sarah; Stembridge, Mike; Shave, Rob; Hoffman, Martin; Whyte, Greg; Somauroo, John; Sharma, Sanjay; George, Keith (Springer, 2015)OBJECTIVES: The traditional view of differential left ventricular adaptation to training type has been questioned. Right ventricular (RV) data in athletes are emerging but whether training type mediates this is not clear. ...
CHANGES IN LEFT VENTRICULAR FUNCTION AND MORPHOLOGY IN RESPONSE TO HIGH-INTENSITY, CROSS-TRAINING. Edwards, Daniel (University of Wales Institute Cardiff, 2012)It is a widely accepted concept that different exercise modalities produce different effects of myocardial hypertrophy in athletes; a sport-specific hypothesis proposed by Morganroth et al. (1977). The literature would ...