Show simple item record

dc.contributor.authorDawkins, Tony
dc.contributor.authorCurry, Bryony
dc.contributor.authorDrane, Aimee L.
dc.contributor.authorLord, Rachel
dc.contributor.authorRichards, Cory
dc.contributor.authorBrown, Megan
dc.contributor.authorPugh, Christopher J. A.
dc.contributor.authorLodge, Freya
dc.contributor.authorYousef, Zaheer
dc.contributor.authorStembridge, Mike
dc.contributor.authorShave, Rob
dc.date.accessioned2020-09-21T15:14:26Z
dc.date.available2020-09-21T15:14:26Z
dc.date.issued2020-09-01
dc.identifierhttps://repository.cardiffmet.ac.uk/bitstream/id/46578/Dawkins,%20Stembridge%20et%20al.,%202020.pdf
dc.identifier.citationDawkins, T.G., Curry, B.A., Drane, A.L., Lord, R.N., Richards, C., Brown, M., Pugh, C.J., Lodge, F., Yousef, Z., Stembridge, M. and Shave, R.E. (2020) 'Stimulus-specific functional remodeling of the left ventricle in endurance and resistance-trained men', American Journal of Physiology-Heart and Circulatory Physiology, 319(3), pp.H632-H641.en_US
dc.identifier.issn0363-6135
dc.identifier.issn1522-1539 (online)
dc.identifier.urihttp://hdl.handle.net/10369/11153
dc.descriptionArticle published in American Journal of Physiology-Heart and Circulatory Physiology available at https://doi.org/10.1152/ajpheart.00233.2020en_US
dc.description.abstractLeft ventricular (LV) structural remodeling following athletic training has been evidenced through training-specific changes in wall thickness and geometry. Whether the LV response to changes in hemodynamic load also adapts in a training-specific manner is unknown. Using echocardiography, we examined LV responses of endurance-trained (n = 15), resistance-trained (n = 14), and nonathletic men (n = 13) to 1) 20, 40, and 60% one repetition-maximum (1RM), leg-press exercise and 2) intravascular Gelofusine infusion (7 mL/kg) with passive leg raise. While resting heart rate was lower in endurance-trained participants versus controls (P = 0.001), blood pressure was similar between groups. Endurance-trained individuals had lower wall thickness but greater LV mass relative to body surface area versus controls, with no difference between resistance-trained individuals and controls. Leg press evoked a similar increase in blood pressure; however, resistance-trained participants preserved stroke volume (SV; −3 ± 8%) versus controls at 60% 1RM (−15 ± 7%, P = 0.001). While the maintenance of SV was related to the change in longitudinal strain across all groups (R = 0.537; P = 0.007), time-to-peak strain was maintained in resistance-trained but delayed in endurance-trained individuals (1 vs. 12% delay; P = 0.021). Volume infusion caused a similar increase in end-diastolic volume (EDV) and SV across groups, but leg raise further increased EDV only in endurance-trained individuals (5 ± 5 to 8 ± 5%; P = 0.018). Correlation analysis revealed a relationship between SV and longitudinal strain following infusion and leg raise (R = 0.334, P = 0.054); however, we observed no between-group differences in longitudinal myocardial mechanics. In conclusion, resistance-trained individuals better maintained SV during pressure loading, whereas endurance-trained individuals demonstrated greater EDV reserve during volume loading. These data provide novel evidence of training-specific LV functional remodeling. NEW & NOTEWORTHY Training-specific functional remodeling of the LV in response to different loading conditions has been recently suggested, but not experimentally tested in the same group of individuals. Our data provide novel evidence of a dichotomous, training-specific LV adaptive response to hemodynamic pressure or volume loading.en_US
dc.language.isoenen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.ispartofseriesAmerican Journal of Physiology - Heart and Circulatory Physiology;
dc.titleStimulus-specific functional remodeling of the left ventricle in endurance and resistance-trained menen_US
dc.typeArticleen_US
dc.typeacceptedVersion
dcterms.dateAccepted2020-08-03
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecordhttps://doi.org/10.1152/ajpheart.00233.2020
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
rioxxterms.licenseref.startdate2021-09-01
rioxxterms.publicationdate2020-09-01
dc.date.refFCD2020-09-21
rioxxterms.freetoread.startdate2021-09-01
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record