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dc.contributor.authorBerthelsen, Lindsey
dc.contributor.authorFraser, Graham
dc.contributor.authorSimpson, Lydia
dc.contributor.authorVanden Berg, Emily
dc.contributor.authorBusch, Stephen A.
dc.contributor.authorSteele, Andrew R.
dc.contributor.authorMeah, Victoria L.
dc.contributor.authorLawley, Justin
dc.contributor.authorFigueroa-Mujica, Romulo
dc.contributor.authorVizcardo-Galindo, Gustavo
dc.contributor.authorVillafuerte, Francisco
dc.contributor.authorGasho, Chris
dc.contributor.authorWillie, Christopher
dc.contributor.authorTymko, Michael M.
dc.contributor.authorAinslie, Philip N.
dc.contributor.authorStembridge, Mike
dc.contributor.authorMoore, Jonathan P.
dc.contributor.authorSteinback, Craig D.
dc.date.accessioned2020-09-21T15:56:57Z
dc.date.available2020-09-21T15:56:57Z
dc.date.issued2020-09-28
dc.identifier.citationBerthelsen, L.F., Fraser, G.M., Simpson, L.L., Vanden Berg, E.R., Busch, S.A., Steele, A.R., Meah, V.L., Lawley, J.S., Figueroa-Mujíca, R., Vizcardo Galindo, G.A., Villafuerte, F.C., Gasho, C., Willie, C., Tymko, M., Ainslie, P., Stembridge, M., Moore, J.P. & Steinback, C.D. (2020) 'Highs and Lows of Sympathetic Neuro-cardiovascular Transduction: Influence of Altitude Acclimatization and Adaptation', American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.00364.2020
dc.identifier.issn0363-6135
dc.identifier.issn1522-1539 (online)
dc.identifier.urihttp://hdl.handle.net/10369/11154
dc.descriptionArticle published in AJP- Heart and Circulatory Physiology, available at https://doi.org/10.1152/ajpheart.00364.2020en_US
dc.description.abstractHigh-altitude (>2500m) exposure results in increased muscle sympathetic nervous activity (MSNA) in acclimatizing lowlanders. However, little is known about how altitude affects MSNA in 66 indigenous high-altitude populations. Additionally, the relationship between MSNA and blood 67 pressure regulation (i.e., neurovascular transduction) at high-altitude is unclear. We sought to 68 determine 1) how high-altitude effects neuro-cardiovascular transduction and 2) whether 69 differences exist in neuro-cardiovascular transduction between low and high-altitude 70 populations. Measurements of MSNA (microneurography), mean arterial blood pressure (MAP; 71 finger photoplethysmography), and heart rate (electrocardiogram) were collected in: I) 72 lowlanders (n=14) at low (344m) and high-altitude (5050m), II) Sherpa highlanders (n=8; 73 5050m), and III) Andean (with and without excessive erythrocytosis) highlanders (n=15; 74 4300m). Cardiovascular responses to MSNA burst sequences (i.e. singlet, couplet, triplet, and 75 quadruplets) were quantified using custom software (coded in MATLAB, v2015b). Slopes were 76 generated for each individual based on peak responses and normalized total MSNA. High 77 altitude reduced neuro-cardiovascular transduction in lowlanders (MAP slope: high-altitude, 78 0.0075±0.0060 vs low-altitude, 0.0134±0.080; p=0.03). Transduction was elevated in Sherpa 79 (MAP slope, 0.012±0.007) compared to Andeans (0.003±0.002; p=0.001). MAP transduction 80 was not statistically different between acclimatizing lowlanders and Sherpa (MAP slope, p=0.08) 81 or Andeans (MAP slope, p=0.07). When accounting for resting MSNA (ANCOVA), transduction 82 was inversely related to basal MSNA (bursts/min) independent of population (RRI, r= 0.578 83 p<0.001; MAP, r= -0.627 p<0.0001). Our results demonstrate transduction is blunted in 84 individuals with higher basal MSNA, suggesting blunted neuro-cardiovascular transduction is a 85 physiological adaptation to elevated MSNA rather than an effect or adaptation specific to 86 chronic hypoxic exposure.en_US
dc.language.isoenen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.ispartofseriesAmerican Journal of Physiology - Heart and Circulatory Physiology;
dc.titleHighs and Lows of Sympathetic Neuro-cardiovascular Transduction: Influence of Altitude Acclimatization and Adaptationen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1152/ajpheart.00364.2020
dcterms.dateAccepted2020-09-21
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
rioxxterms.freetoread.startdate2021-09-28
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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