Higher sRAGE levels predict mortality in frail older adults with cardiovascular disease

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Author
Butcher, Lee
Carnicero, Jose Antonio
Peres, Karine
Colpo, Marco
Gomez-Cabrero, David
Dartigues, Jean-François
Bandinelli, Stefania
Garcia-Garcia, Francisco Jose
Manas, Leocadio Rodriguez
Erusalimsky, Jorge
Date
2021-01-21Acceptance date
2020-10-14
Type
Article
Publisher
Karger
ISSN
0304-324X
1423-0003 (online)
Embargoed until
2022-01-21
Metadata
Show full item recordAbstract
Introduction: The evidence that blood levels of the soluble receptor for advanced
glycation end products (sRAGE) predict mortality in people with cardiovascular
diseases (CVD) is inconsistent. To clarify this matter, we investigated if frailty status
influences this association.
Methods: We analysed data of 1016 individuals (median age, 75 years) from three
population-based European cohorts, enrolled in the FRAILOMIC project. Participants
were stratified by history of CVD and frailty status. Mortality was recorded during 8
years of follow-up.
Results: In adjusted Cox regression models baseline serum sRAGE was positively
associated with an increased risk of mortality in participants with CVD (HR 1.64,
95%CI 1.09-2.49, P=0.019), but not in non-CVD. Within the CVD group, the risk of
death was markedly enhanced in the frail subgroup (CVD-F, HR 1.97, 95%CI 1.18-
3.29, P=0.009), compared to the non-frail subgroup (CVD-NF, HR 1.50, 95%CI 0.71-
3.15, P=0.287). Kaplan-Meier analysis showed that the median survival time of CVDF with high sRAGE (>1554 pg/mL) was 2.9 years shorter than that of CVD-F with low
sRAGE, whereas no survival difference was seen for CVD-NF. Area under the ROC
curve analysis demonstrated that for CVD-F, addition of sRAGE to the prediction
model increased its prognostic value.
Conclusions: Frailty status influences the relationship between sRAGE and
mortality in older adults with CVD. sRAGE could be used as a prognostic marker of
mortality for these individuals, particularly if they are also frail.
Journal/conference proceeding
Gerontology;
Citation
Butcher, L., Carnicero, J.A., Pérès, K., Colpo, M., Cabrero, D.G., Dartigues, J.F., Bandinelli, S., Garcia-Garcia, F.J., Rodríguez-Mañas, L., Erusalimsky, J.D. and FRAILOMIC Consortium (2021) 'Higher sRAGE levels predict mortality in frail older adults with cardiovascular disease', Gerontology, pp.1-9. https://doi.org/10.1159/000512287
Description
Article published in Gerontology available at https://doi.org/10.1159/000512287
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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