Higher sRAGE levels predict mortality in frail older adults with cardiovascular disease
Carnicero, Jose Antonio
Garcia-Garcia, Francisco Jose
Manas, Leocadio Rodriguez
Wedi’i wahardd nes
MetadataDangos cofnod eitem llawn
Introduction: The evidence that blood levels of the soluble receptor for advanced glycation end products (sRAGE) predict mortality in people with cardiovascular diseases (CVD) is inconsistent. To clarify this matter, we investigated if frailty status influences this association. Methods: We analysed data of 1016 individuals (median age, 75 years) from three population-based European cohorts, enrolled in the FRAILOMIC project. Participants were stratified by history of CVD and frailty status. Mortality was recorded during 8 years of follow-up. Results: In adjusted Cox regression models baseline serum sRAGE was positively associated with an increased risk of mortality in participants with CVD (HR 1.64, 95%CI 1.09-2.49, P=0.019), but not in non-CVD. Within the CVD group, the risk of death was markedly enhanced in the frail subgroup (CVD-F, HR 1.97, 95%CI 1.18- 3.29, P=0.009), compared to the non-frail subgroup (CVD-NF, HR 1.50, 95%CI 0.71- 3.15, P=0.287). Kaplan-Meier analysis showed that the median survival time of CVDF with high sRAGE (>1554 pg/mL) was 2.9 years shorter than that of CVD-F with low sRAGE, whereas no survival difference was seen for CVD-NF. Area under the ROC curve analysis demonstrated that for CVD-F, addition of sRAGE to the prediction model increased its prognostic value. Conclusions: Frailty status influences the relationship between sRAGE and mortality in older adults with CVD. sRAGE could be used as a prognostic marker of mortality for these individuals, particularly if they are also frail.
Butcher, L., Carnicero, J.A., Pérès, K., Colpo, M., Cabrero, D.G., Dartigues, J.F., Bandinelli, S., Garcia-Garcia, F.J., Rodríguez-Mañas, L., Erusalimsky, J.D. and FRAILOMIC Consortium (2021) 'Higher sRAGE levels predict mortality in frail older adults with cardiovascular disease', Gerontology, pp.1-9. https://doi.org/10.1159/000512287
Dynodwr Gwrthrych Digidol (DOI)https://doi.org/10.1159/000512287
Article published in Gerontology available at https://doi.org/10.1159/000512287
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
Increased levels of soluble Receptor for Advanced Glycation End-Products (RAGE) are associated with a higher risk of mortality in frail older adults Butcher, Lee; Carnicero, Jose; Gomez-Cabrero, David; Dartigues, Jean-Francois; Peres, Karine; Garcia-Garcia, Francisco Jose; Rodriguez-Mañas, Leocadio; Erusalimsky, Jorge (Oxford University Press, 2019-06-18)Objective: To evaluate the relationship between serum levels of the soluble Receptor for Advanced Glycation End-products (sRAGE) and mortality in frail and non-frail older adults. Methods: We studied 691 subjects (141 ...
The effects of the dietary lipid Conjugated Linoleic Acid (CLA) and its 9:11 isomer on the expression of soluble receptors for advanced glycation end-products (sRAGE) in THP-1 Monocytic cells Davies, Rhodri (University of Wales Institute Cardiff, 2012)This study aimed to investigate the hypothesis that the dietary lipid Conjugated Linoleic Acid (CLA) and its 9:11 isomer are capable of inducing the expression of the soluble variant of the Receptor for Advance Glycation ...
Drew, Ellie (Cardiff Metropolitan University, 2017-06-01)The binding of Advanced Glycation Endproducts (AGEs) to the Receptor for Advanced Glycation Endproducts (RAGE) has been implicated in the pathogenesis of many inflammatory disorders. The RAGE mediated pathway leads to ...