Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus
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The objective of this study was to investigate alterations to brain activity and functional connectivity in patients with tinnitus, exploring neural features in the transition from acute to chronic phantom perception. Twenty‐four patients with acute tinnitus, 23 patients with chronic tinnitus, and 32 healthy controls were recruited. High‐density electroencephalography (EEG) was used to explore changes in brain areas and functional connectivity in different groups. When compared with healthy subjects, acute tinnitus patients had a significant reduction in superior frontal cortex activity across all frequency bands, whereas chronic tinnitus patients had a significant reduction in the superior frontal cortex at beta 3 and gamma frequency bands as well as a significant increase in the inferior frontal cortex at delta‐band and superior temporal cortex at alpha 1 frequency band. When compared to the chronic tinnitus group, the acute tinnitus group activity was significantly increased in the middle frontal and parietal gyrus at the gamma‐band. Functional connectivity analysis showed that the chronic tinnitus group had increased connections between the parahippocampus gyrus, posterior cingulate cortex, and precuneus when compared with the healthy group. Alterations of local brain activity and connections between the parahippocampus gyrus and other nonauditory areas appeared in the transition from acute to chronic tinnitus. This indicates that the appearance and development of tinnitus is a dynamic process involving aberrant local neural activity and abnormal connectivity in multifunctional brain networks.
Human Brain Mapping;
Lan, L., Li, J., Chen, Y., Chen, W., Li, W., Zhao, F., Chen, G., Liu, J., Chen, Y., Li, Y., Wang, C.D., Zheng, Y., Cai, Y. (2020) 'Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus', Human Brain Mapping. https://doi.org/10.1002/hbm.25238
Article published in Human Brain Mapping available open access at https://doi.org/10.1002/hbm.25238
Key R&D Program of Guangdong Province, China, Grant/Award Number: 2018B030339001; the Fundamental Research Funds for the Central Universities, Grant/Award Number: 20ykpy91; the Medical artificial intelligence project of Sun Yat‐sen Memorial Hospital, Grant/Award Number: YXYGZN201904; Sun Yat‐Sen Clinical Research Cultivating Program, Grant/Award Number: SYS‐Q‐20190; National Natural Science Foundation of China, Grant/Award Number: 82071062
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