Show simple item record

dc.contributor.authorLan, Liping
dc.contributor.authorLi, Jiahong
dc.contributor.authorChen, Yanhong
dc.contributor.authorChen, Wan
dc.contributor.authorLi, Wenrui
dc.contributor.authorZhao, Fei
dc.contributor.authorChen, Guisheng
dc.contributor.authorLiu, Jiahao
dc.contributor.authorChen, Yuchen
dc.contributor.authorLi, Yuanqing
dc.contributor.authorWang, Chang-Dong
dc.contributor.authorZheng, Yiqing
dc.contributor.authorCai, Yuexin
dc.date.accessioned2020-11-20T10:13:16Z
dc.date.available2020-11-20T10:13:16Z
dc.date.issued2020-10-13
dc.identifier.citationLan, L., Li, J., Chen, Y., Chen, W., Li, W., Zhao, F., Chen, G., Liu, J., Chen, Y., Li, Y., Wang, C.D., Zheng, Y., Cai, Y. (2020) 'Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus', Human Brain Mapping. https://doi.org/10.1002/hbm.25238en_US
dc.identifier.issn1065-9471
dc.identifier.issn1097-0193 (electronic)
dc.identifier.urihttp://hdl.handle.net/10369/11223
dc.descriptionArticle published in Human Brain Mapping available open access at https://doi.org/10.1002/hbm.25238en_US
dc.description.abstractThe objective of this study was to investigate alterations to brain activity and functional connectivity in patients with tinnitus, exploring neural features in the transition from acute to chronic phantom perception. Twenty‐four patients with acute tinnitus, 23 patients with chronic tinnitus, and 32 healthy controls were recruited. High‐density electroencephalography (EEG) was used to explore changes in brain areas and functional connectivity in different groups. When compared with healthy subjects, acute tinnitus patients had a significant reduction in superior frontal cortex activity across all frequency bands, whereas chronic tinnitus patients had a significant reduction in the superior frontal cortex at beta 3 and gamma frequency bands as well as a significant increase in the inferior frontal cortex at delta‐band and superior temporal cortex at alpha 1 frequency band. When compared to the chronic tinnitus group, the acute tinnitus group activity was significantly increased in the middle frontal and parietal gyrus at the gamma‐band. Functional connectivity analysis showed that the chronic tinnitus group had increased connections between the parahippocampus gyrus, posterior cingulate cortex, and precuneus when compared with the healthy group. Alterations of local brain activity and connections between the parahippocampus gyrus and other nonauditory areas appeared in the transition from acute to chronic tinnitus. This indicates that the appearance and development of tinnitus is a dynamic process involving aberrant local neural activity and abnormal connectivity in multifunctional brain networks.en_US
dc.description.sponsorshipKey R&D Program of Guangdong Province, China, Grant/Award Number: 2018B030339001; the Fundamental Research Funds for the Central Universities, Grant/Award Number: 20ykpy91; the Medical artificial intelligence project of Sun Yat‐sen Memorial Hospital, Grant/Award Number: YXYGZN201904; Sun Yat‐Sen Clinical Research Cultivating Program, Grant/Award Number: SYS‐Q‐20190; National Natural Science Foundation of China, Grant/Award Number: 82071062en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesHuman Brain Mapping;
dc.titleAlterations of brain activity and functional connectivity in transition from acute to chronic tinnitusen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1002/hbm.25238
dcterms.dateAccepted2020-09-29
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2020-10-20


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record