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dc.contributor.authorWillie, Christopher
dc.contributor.authorPatrician, Alexander
dc.contributor.authorHoiland, Ryan
dc.contributor.authorWilliams, Alexandra
dc.contributor.authorGasho, Chris
dc.contributor.authorSubedi, Prajan
dc.contributor.authorAnholm, James
dc.contributor.authorDrane, Aimee L.
dc.contributor.authorTymko, Michael
dc.contributor.authorNowak-Flück, Daniela
dc.contributor.authorPlato, Sawyer
dc.contributor.authorMcBride, Emily
dc.contributor.authorVaroli, Giovanfrancesco
dc.contributor.authorBinsted, Gord
dc.contributor.authorEller, Lindsay
dc.contributor.authorReimer, Raylene
dc.contributor.authorMacLeod, David
dc.contributor.authorStembridge, Mike
dc.contributor.authorAinslie, Philip
dc.date.accessioned2020-12-17T17:14:02Z
dc.date.available2020-12-17T17:14:02Z
dc.date.issued2021-01-14
dc.identifier.citationWillie, C.K., Patrician, A., Hoiland, R.L., Williams, A.M., Gasho, C., Subedi, P., Anholm, J., Drane, A., Tymko, M.M., Nowak‐Flück, D., Plato, S., McBride, E., Varoli, G., Binsted, G., Eller, L., Reimer, R., MacLeod, D., Stembridge, M., Ainslie, P.(2021) Influence of iron manipulation on hypoxic pulmonary vasoconstriction and pulmonary reactivity during ascent and acclimatization to 5050 m. The Journal of Physiology. https://doi.org/10.1113/JP281114
dc.identifier.issn0022-3751
dc.identifier.issn1469-7793 (electronic)
dc.identifier.urihttp://hdl.handle.net/10369/11252
dc.descriptionArticle published in Journal of Physiology available at https://doi.org/10.1113/JP281114en_US
dc.description.abstractTo examine the adaptational role of iron bioavailability on the pulmonary vascular responses to acute and chronic hypobaric hypoxia, the hematological and cardiopulmonary profile of lowlanders and Sherpa were determined during: 1) a nine-day ascent to 5050m (20 lowlanders; 12 Sherpa), and 2) following partial acclimatization (11±4 days) to 5050m (18 lowlanders; 20 Sherpa), where both groups received either an i.v. infusion of iron (iron (III)-hydroxide sucrose) or an iron chelator (desferrioxamine). During ascent, there were reductions in iron status in both lowlanders and Sherpa; however, Sherpa appeared to demonstrate a more efficient capacity to mobilize stored iron, compared to lowlanders, when expressed as a hepcidin per unit change in either body iron or the soluble transferrin receptor index, between 3400-5050m (p=0.016 and p=0.029 respectively). The rise in pulmonary artery systolic pressure (PASP) was blunted in Sherpa, compared to lowlanders during ascent; however, PASP was comparable in both groups upon arrival to 5050m. Following partial acclimatization, despite Sherpa demonstrating a blunted hypoxic ventilatory response and greater resting hypoxemia, they had similar hypoxic pulmonary vasoconstriction when compared to lowlanders at rest. Iron-infusion attenuated PASP in both groups at rest (p=0.005), while chelation did not exaggerate PASP in either group at rest or during exaggerated hypoxemia (PIO2=67 mmHg). During exercise at 25% peak wattage, PASP was only consistently elevated in Sherpa, which persisted following both iron infusion or chelation. These findings provide new evidence on the complex interplay of iron regulation on pulmonary vascular regulation during acclimatization and adaptation to high altitude.en_US
dc.description.sponsorshipCanada Research Chairs (Chaires de recherche du Canada): Philip N Ainslie, -; Gouvernement du Canada | Natural Sciences andEngineering Research Council of Canada (Conseil de Recherches enSciences Naturelles et en Génie du Canada): Alexander Patrician, Ryan LHoiland, Michael M Tymkoen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesJournal of Physiology;
dc.subjectironen_US
dc.subjectdesferrioxamineen_US
dc.subjectpulmonary vascular reactivityen_US
dc.subjecthypoxic pulmonary vasoconstrictionen_US
dc.subjecthypoxiaen_US
dc.subjectsherpaen_US
dc.titleInfluence of iron manipulation on hypoxic pulmonary vasoconstriction and pulmonary reactivity during ascent and acclimatization to 5050 men_US
dc.typeArticleen_US
dcterms.dateAccepted2020-12-16
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
rioxxterms.freetoread.startdate2022-01-14
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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