• English
    • Welsh
  • English 
    • English
    • Welsh
  • Login
Search DSpace:
  • Home
  • Research at Cardiff Met
  • Library Services
  • Contact Us
View item 
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Health and Risk Management
  • View item
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Health and Risk Management
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder

Thumbnail
Author
Charney, A.W.
Ruderfer, D. M.
Stahl, E. A.
Moran, J. L.
Chambert, K.
Belliveau, R. A.
Forty, L.
Gordon-Smith, K.
Di Florio, Arianna
Lee, P. H.
Bromet, E. J.
Buckley, P. F.
Escamilla, M. A.
Fanous, A. H.
Fochtmann, L. J.
Lehrer, D. S.
Malaspina, D.
Marder, S. R.
Morley, C. P.
Nicolini, H.
Perkins, D. O.
Rakofsky, J. J.
Rapaport, M. H.
Medeiros, H.
Sobell, J. L.
Green, Elaine
Date
2017-01-10
Acceptance date
2016-09-28
Type
Article
Publisher
Nature
ISSN
2158-3188 (electronic)
Metadata
Show full item record
Abstract
We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta-analysis was performed with prior results from the Psychiatric Genomics Consortium Bipolar Disorder Working Group for a combined sample of 13 902 cases and 19 279 controls. We identified eight genome-wide significant, associated regions, including a novel associated region on chromosome 10 (rs10884920; P = 3.28 × 10− 8) that includes the brain-enriched cytoskeleton protein adducin 3 (ADD3), a non-coding RNA, and a neuropeptide-specific aminopeptidase P (XPNPEP1). Our large sample size allowed us to test the heritability and genetic correlation of BD subtypes and investigate their genetic overlap with schizophrenia and major depressive disorder. We found a significant difference in heritability of the two most common forms of BD (BD I SNP-h2 = 0.35; BD II SNP-h2 = 0.25; P = 0.02). The genetic correlation between BD I and BD II was 0.78, whereas the genetic correlation was 0.97 when BD cohorts containing both types were compared. In addition, we demonstrated a significantly greater load of polygenic risk alleles for schizophrenia and BD in patients with BD I compared with patients with BD II, and a greater load of schizophrenia risk alleles in patients with the bipolar type of schizoaffective disorder compared with patients with either BD I or BD II. These results point to a partial difference in the genetic architecture of BD subtypes as currently defined.
Journal/conference proceeding
Translational Psychiatry;
Citation
Charney, A W, Ruderfer, D M, Stahl, E A, Moran, J L, Chambert, K, Belliveau, R A, Forty, L, Gordon-Smith, K, Di Florio, Arianna, Lee, P H, Bromet, E J, Buckley, P F, Escamilla, M A, Fanous, A H, Fochtmann, L J, Lehrer, D S, Malaspina, D, Marder, S R, Morley, C P, Nicolini, H, Perkins, D O, Rakofsky, J J, Rapaport, M H, Medeiros, H, Sobell, J L, Green, E K, Backlund, L, Bergen, S E, Juréus, A, Schalling, M, Lichtenstein, P, Roussos, P, Knowles, J A, Jones, Ian, Jones, L A, Hultman, C M, Perlis, R H, Purcell, S M, McCarroll, S A, Pato, C N, Pato, M T, Craddock, Nicholas, Landén, M, Smoller, J W and Sklar, P (2017) 'Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder', Translational Psychiatry, 7(1), pp.e993-e993. http://dx.doi.org/10.1038/tp.2016.242
URI
http://hdl.handle.net/10369/11257
DOI
http://dx.doi.org/10.1038/tp.2016.242
Description
Article published in Translational Psychiatry available open access at http://dx.doi.org/10.1038/tp.2016.242
Rights
http://creativecommons.org/licenses/by/2.5/
Collections
  • Health and Risk Management [396]

Related items

Showing items related by title, author, subject and abstract.

  • Thumbnail

    Genome‐wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type 

    Green, Elaine; Di Florio, Arianna; Forty, Liz; Gordon-Smith, Katherine; Grozeva, Detelina; Fraser, Christine; Richards, Alexander L.; Moran, Jennifer L.; Purcell, Shaun; Sklar, Pamela; Kirov, George; Owen, Michael J.; O'Donovan, Michael C.; Craddock, Nick; Jones, Lisa; Jones, Ian R. (Wiley, 2017-08-29)
    Studies have suggested that Research Diagnostic Criteria for Schizoaffective disorder Bipolar type (RDC-SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated ...
  • Thumbnail

    Contribution of Rare Copy Number Variants to Bipolar Disorder Risk Is Limited to Schizoaffective Cases 

    Charney, Alexander; Stahl, Eli; Green, Elaine (Elsevier, 2018-12-20)
    Background Genetic risk for bipolar disorder (BD) is conferred through many common alleles, while a role for rare copy number variants (CNVs) is less clear. Subtypes of BD including schizoaffective disorder bipolar type ...
  • Thumbnail

    Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder 

    Song, J.; Bergen, S.E.; Di Florio, A.; Karlsson, R.; Charney, A.; Ruderfer, D. M.; Stahl, E. A.; Chambert, K. D.; Moran, J. L.; Gordon-Smith, K.; Forty, L.; Green, Elaine (Springer Nature, 2015-10-27)
    Lithium is the mainstay prophylactic treatment for bipolar disorder (BD), but treatment response varies considerably across individuals. Patients who respond well to lithium treatment might represent a relatively homogeneous ...

Browse

DSpace at Cardiff MetCommunities & CollectionsBy issue dateAuthorsTitlesSubjectsThis collectionBy issue dateAuthorsTitlesSubjects

My Account

Login

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Contact us | Send feedback | Administrator