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Genome‐wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type

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Author
Green, Elaine
Di Florio, Arianna
Forty, Liz
Gordon-Smith, Katherine
Grozeva, Detelina
Fraser, Christine
Richards, Alexander L.
Moran, Jennifer L.
Purcell, Shaun
Sklar, Pamela
Kirov, George
Owen, Michael J.
O'Donovan, Michael C.
Craddock, Nick
Jones, Lisa
Jones, Ian R.
Date
2017-08-29
Acceptance date
2017-06-30
Type
Article
Publisher
Wiley
ISSN
1552-4841
1552-485X (electronic)
Metadata
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Abstract
Studies have suggested that Research Diagnostic Criteria for Schizoaffective disorder Bipolar type (RDC-SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated with RDC-SABP we have performed a replication study using independent RDC-SABP cases (n=144) and controls (n=6,559), focusing on the 10 loci that P-value <10-5 for RDC-SABP in the Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder sample using ‘researcher-specific SNPs’ represented on the custom array, the ImmunoChip. Combining the WTCCC and replication datasets by meta-analysis (combined RDC-SABP, n=423, Controls, n=9,494) we observed genome wide significance association at one SNP, rs2352974, located within the intron of the gene TRAIP on chromosome 3p21.31. This locus did not reach genome wide significance in bipolar disorder or schizophrenia large psychiatric genomic consortium datasets, suggesting that it may be a relatively specific genetic risk for the bipolar subtype of schizoaffective disorder.
Journal/conference proceeding
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics;
Citation
Green, Elaine K., Di Florio, Arianna, Forty, Liz, Gordon-Smith, Katherine, Grozeva, Detelina, Fraser, Christine, Richards, Alexander L., Moran, Jennifer L., Purcell, Shaun, Sklar, Pamela, Kirov, George, Owen, Michael J., O'Donovan, Michael C., Craddock, Nick, Jones, Lisa and Jones, Ian R. (2017) 'Genome-wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174 (8) , pp. 767-771. 10.1002/ajmg.b.32572
URI
http://hdl.handle.net/10369/11259
DOI
http://dx.doi.org/10.1002/ajmg.b.32572
Description
Article published in American Journal of Medical Genetics Part B: Neuropsychiatric Genetics available at http://dx.doi.org/10.1002/ajmg.b.32572
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  • Health and Risk Management [387]

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