Genome‐wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type

View/ open
Author
Green, Elaine
Di Florio, Arianna
Forty, Liz
Gordon-Smith, Katherine
Grozeva, Detelina
Fraser, Christine
Richards, Alexander L.
Moran, Jennifer L.
Purcell, Shaun
Sklar, Pamela
Kirov, George
Owen, Michael J.
O'Donovan, Michael C.
Craddock, Nick
Jones, Lisa
Jones, Ian R.
Date
2017-08-29Acceptance date
2017-06-30
Type
Article
Publisher
Wiley
ISSN
1552-4841
1552-485X (electronic)
Metadata
Show full item recordAbstract
Studies have suggested that Research Diagnostic Criteria for Schizoaffective disorder Bipolar type (RDC-SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated with RDC-SABP we have performed a replication study using independent RDC-SABP cases (n=144) and controls (n=6,559), focusing on the 10 loci that P-value <10-5 for RDC-SABP in the Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder sample using ‘researcher-specific SNPs’ represented on the custom array, the ImmunoChip. Combining the WTCCC and replication datasets by meta-analysis (combined RDC-SABP, n=423, Controls, n=9,494) we observed genome wide significance association at one SNP, rs2352974, located within the intron of the gene TRAIP on chromosome 3p21.31. This locus did not reach genome wide significance in bipolar disorder or schizophrenia large psychiatric genomic consortium datasets, suggesting that it may be a relatively specific genetic risk for the bipolar subtype of schizoaffective disorder.
Journal/conference proceeding
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics;
Citation
Green, Elaine K., Di Florio, Arianna, Forty, Liz, Gordon-Smith, Katherine, Grozeva, Detelina, Fraser, Christine, Richards, Alexander L., Moran, Jennifer L., Purcell, Shaun, Sklar, Pamela, Kirov, George, Owen, Michael J., O'Donovan, Michael C., Craddock, Nick, Jones, Lisa and Jones, Ian R. (2017) 'Genome-wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174 (8) , pp. 767-771. 10.1002/ajmg.b.32572
Description
Article published in American Journal of Medical Genetics Part B: Neuropsychiatric Genetics available at http://dx.doi.org/10.1002/ajmg.b.32572
Collections
Related items
Showing items related by title, author, subject and abstract.
-
Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder
Charney, A.W.; Ruderfer, D. M.; Stahl, E. A.; Moran, J. L.; Chambert, K.; Belliveau, R. A.; Forty, L.; Gordon-Smith, K.; Di Florio, Arianna; Lee, P. H.; Bromet, E. J.; Buckley, P. F.; Escamilla, M. A.; Fanous, A. H.; Fochtmann, L. J.; Lehrer, D. S.; Malaspina, D.; Marder, S. R.; Morley, C. P.; Nicolini, H.; Perkins, D. O.; Rakofsky, J. J.; Rapaport, M. H.; Medeiros, H.; Sobell, J. L.; Green, Elaine (Nature, 2017-01-10)We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta-analysis was performed with prior results ... -
Contribution of Rare Copy Number Variants to Bipolar Disorder Risk Is Limited to Schizoaffective Cases
Charney, Alexander; Stahl, Eli; Green, Elaine (Elsevier, 2018-12-20)Background Genetic risk for bipolar disorder (BD) is conferred through many common alleles, while a role for rare copy number variants (CNVs) is less clear. Subtypes of BD including schizoaffective disorder bipolar type ... -
Exploring the experience of misdiagnosis within Bipolar Type Two disorder
Smith, Natasha (2018-05-01)Bipolar Type Two disorder (BP- II) is a mental health disorder that is frequently misdiagnosed as depression due to the shared predominant symptom of recurrent, extended periods of depression and unrecognized hypomanic ...