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dc.contributor.authorGreen, Elaine
dc.contributor.authorDi Florio, Arianna
dc.contributor.authorForty, Liz
dc.contributor.authorGordon-Smith, Katherine
dc.contributor.authorGrozeva, Detelina
dc.contributor.authorFraser, Christine
dc.contributor.authorRichards, Alexander L.
dc.contributor.authorMoran, Jennifer L.
dc.contributor.authorPurcell, Shaun
dc.contributor.authorSklar, Pamela
dc.contributor.authorKirov, George
dc.contributor.authorOwen, Michael J.
dc.contributor.authorO'Donovan, Michael C.
dc.contributor.authorCraddock, Nick
dc.contributor.authorJones, Lisa
dc.contributor.authorJones, Ian R.
dc.date.accessioned2021-01-08T15:00:06Z
dc.date.available2021-01-08T15:00:06Z
dc.date.issued2017-08-29
dc.identifier.citationGreen, Elaine K., Di Florio, Arianna, Forty, Liz, Gordon-Smith, Katherine, Grozeva, Detelina, Fraser, Christine, Richards, Alexander L., Moran, Jennifer L., Purcell, Shaun, Sklar, Pamela, Kirov, George, Owen, Michael J., O'Donovan, Michael C., Craddock, Nick, Jones, Lisa and Jones, Ian R. (2017) 'Genome-wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174 (8) , pp. 767-771. 10.1002/ajmg.b.32572en_US
dc.identifier.issn1552-4841
dc.identifier.issn1552-485X (electronic)
dc.identifier.urihttp://hdl.handle.net/10369/11259
dc.descriptionArticle published in American Journal of Medical Genetics Part B: Neuropsychiatric Genetics available at http://dx.doi.org/10.1002/ajmg.b.32572en_US
dc.description.abstractStudies have suggested that Research Diagnostic Criteria for Schizoaffective disorder Bipolar type (RDC-SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated with RDC-SABP we have performed a replication study using independent RDC-SABP cases (n=144) and controls (n=6,559), focusing on the 10 loci that P-value <10-5 for RDC-SABP in the Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder sample using ‘researcher-specific SNPs’ represented on the custom array, the ImmunoChip. Combining the WTCCC and replication datasets by meta-analysis (combined RDC-SABP, n=423, Controls, n=9,494) we observed genome wide significance association at one SNP, rs2352974, located within the intron of the gene TRAIP on chromosome 3p21.31. This locus did not reach genome wide significance in bipolar disorder or schizophrenia large psychiatric genomic consortium datasets, suggesting that it may be a relatively specific genetic risk for the bipolar subtype of schizoaffective disorder.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics;
dc.titleGenome‐wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar typeen_US
dc.typeArticleen_US
dc.typeacceptedVersion
dc.identifier.doihttp://dx.doi.org/10.1002/ajmg.b.32572
dcterms.dateAccepted2017-06-30
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.refexceptionAt the point of acceptance, the staff member to whom the output is attributed was employed at a different UK HEI
dc.date.refFCD2021-01-08


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