A New Look at the Purported Health Benefits of Commercial and Natural Clays
Moses, Rachael L.
Hill, Katja E.
Thomas, David W.
MetadataShow full item record
Clays attributed to have medicinal properties have been used since prehistoric times and are still used today as complementary medicines, which has given rise to unregulated “bioceutical” clays to treat skin conditions. Recently, clays with antibacterial characteristics have been proposed as alternatives to antibiotics, potentially overcoming modern day antibiotic resistance. Clays with suggested antibacterial properties were examined to establish their effects on common wound-infecting bacteria. Geochemical, microscopical, and toxicological characterization of clay particulates, their suspensions and filtered leachates was performed on THP-1 and HaCaT cell lines. Cytoskeletal toxicity, cell proliferation/viability (MTT assays), and migration (scratch wounds) were further evaluated. Clays were assayed for antibacterial efficacy using minimum inhibitory concentration assays. All clays possessed a mineral content with antibacterial potential; however, clay leachates contained insufficient ions to have any antibacterial effects. All clay leachates displayed toxicity towards THP-1 monocytes, while clay suspensions showed less toxicity, suggesting immunogenicity. Reduced clay cytotoxicity on HaCaTs was shown, as many leachates stimulated wound-healing responses. The “Green” clay exhibited antibacterial effects and only in suspension, which was lost upon neutralization. pH and its interaction with clay particle surface charge is more significant than previously understood to emphasize dangers of unregulated marketing and unsubstantiated bioceutical claims
Incledion, A., Boseley, M., Moses, R.L., Moseley, R., Hill, K.E., Thomas, D.W., Adams, R.A., Jones, T.P. and BéruBé, K.A. (2021) 'A New Look at the Purported Health Benefits of Commercial and Natural Clays', Biomolecules, 11(1), p.58. https://doi.org/10.3390/biom11010058
Article published in Biomolecules available open access at https://doi.org/10.3390/biom11010058
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
- Export 
Showing items related by title, author, subject and abstract.
Begum, Nashrena (Cardiff Metropolitan University, 2011)Honey has been used since the ancient times as a naturally remedy to treat wounds and be an antiseptic. It has been recorded in ancient hieroglyphics that selected honeys have been used for different purposes. In this study ...
Henriques, Ana (University of Wales, 2006)Honey is an old remedy recently rediscovered as a possible alternative to modern antibiotics in wound management but its mode of action is not fully understood. The antibacterial activity of honey can be divided into ...
Al-Maaini, Rahma Ali Saleh (University of Wales, 2012)Honey has been shown to have therapeutic properties, which include immunomodulatory and antibacterial activity in vitro and anti-inflammatory, antipyretic and wound healing properties in vivo. A complex mix of factors ...