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dc.contributor.authorIncledion, Alexander
dc.contributor.authorBoseley, Megan
dc.contributor.authorMoses, Rachael L.
dc.contributor.authorMoseley, Ryan
dc.contributor.authorHill, Katja E.
dc.contributor.authorThomas, David W.
dc.contributor.authorAdams, Rachel
dc.contributor.authorJones, Tim
dc.contributor.authorBéruBé, Kelly
dc.date.accessioned2021-01-12T13:41:23Z
dc.date.available2021-01-12T13:41:23Z
dc.date.issued2021-01-05
dc.identifier.citationIncledion, A., Boseley, M., Moses, R.L., Moseley, R., Hill, K.E., Thomas, D.W., Adams, R.A., Jones, T.P. and BéruBé, K.A. (2021) 'A New Look at the Purported Health Benefits of Commercial and Natural Clays', Biomolecules, 11(1), p.58. https://doi.org/10.3390/biom11010058en_US
dc.identifier.issn2218-273X
dc.identifier.urihttp://hdl.handle.net/10369/11263
dc.descriptionArticle published in Biomolecules available open access at https://doi.org/10.3390/biom11010058en_US
dc.description.abstractClays attributed to have medicinal properties have been used since prehistoric times and are still used today as complementary medicines, which has given rise to unregulated “bioceutical” clays to treat skin conditions. Recently, clays with antibacterial characteristics have been proposed as alternatives to antibiotics, potentially overcoming modern day antibiotic resistance. Clays with suggested antibacterial properties were examined to establish their effects on common wound-infecting bacteria. Geochemical, microscopical, and toxicological characterization of clay particulates, their suspensions and filtered leachates was performed on THP-1 and HaCaT cell lines. Cytoskeletal toxicity, cell proliferation/viability (MTT assays), and migration (scratch wounds) were further evaluated. Clays were assayed for antibacterial efficacy using minimum inhibitory concentration assays. All clays possessed a mineral content with antibacterial potential; however, clay leachates contained insufficient ions to have any antibacterial effects. All clay leachates displayed toxicity towards THP-1 monocytes, while clay suspensions showed less toxicity, suggesting immunogenicity. Reduced clay cytotoxicity on HaCaTs was shown, as many leachates stimulated wound-healing responses. The “Green” clay exhibited antibacterial effects and only in suspension, which was lost upon neutralization. pH and its interaction with clay particle surface charge is more significant than previously understood to emphasize dangers of unregulated marketing and unsubstantiated bioceutical claimsen_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofseriesBiomolecules;
dc.titleA New Look at the Purported Health Benefits of Commercial and Natural Claysen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3390/biom11010058
dcterms.dateAccepted2020-12-31
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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