Reduced Functional Connectivity in Children With Congenital Cataracts Using Resting-State Electroencephalography Measurement
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Objectives: Numerous task-based functional magnetic resonance imaging studies indicate the presence of compensatory functional improvement in patients with congenital cataracts. However, there is neuroimaging evidence that shows decreased sensory perception or cognition information processing related to visual dysfunction, which favors a general loss hypothesis. This study explored the functional connectivity between visual and other networks in children with congenital cataracts using resting state electroencephalography. Methods: Twenty-one children with congenital cataracts (age: 8.02 ± 2.03 years) and thirty-five sex- and age-matched normal sighted controls were enrolled to investigate functional connectivity between the visual cortex and the default mode network, the salience network, and the cerebellum network during resting state electroencephalography (eyes closed) recordings. Result: The congenital cataract group was less active, than the control group, in the occipital, temporal, frontal and limbic lobes in the theta, alpha, beta1 and beta2 frequency bands. Additionally, there was reduced alpha-band connectivity between the visual and somatosensory cortices and between regions of the frontal and parietal cortices associated with cognitive and attentive control. Conclusion: The results indicate abnormalities in sensory, cognition, motion and execution functional connectivity across the developing brains of children with congenital cataracts when compared with normal controls. Reduced frontal alpha activity and alpha-band connectivity between the visual cortex and salience network might reflect attenuated inhibitory information flow, leading to higher attentional states, which could contribute to adaptation of environmental change in this group of patients.
Frontiers in Neuroscience;
Chen, W., Lan, L., Xiao, W., Li, J., Liu, J., Zhao, F., Wang, C.D., Zheng, Y., Chen, W. and Cai, Y. (2021) 'Reduced functional connectivity in children with congenital cataracts using resting-state electroencephalography measurement', Frontiers in Neuroscience, 15, p.404. https://doi.org/10.3389/fnins.2021.657865
Article published in Frontiers in Neuroscience available open access at https://doi.org/10.3389/fnins.2021.657865
This work was funded by Key R&D Program of Guangdong Province, China (Grant No. 2018B030339001), the National Natural Science Foundation of China (82071062 and 82000873), the National Key Research and Development Project (2020YFC2008202), the Fund for the Natural Science Foundation of Guangdong Province (2020A1515010987), Medical Artificial Intelligence Project of Sun Yat-sen Memorial Hospital (YXYGZN201904), Fundamental Research Funds for the Central Universities (20ykpy91), and the Fundamental Research Funds for the Central Universities (19lgjc10).
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