The influence of anesthesia with and without medetomidine on cardiac structure and function in sanctuary captive chimpanzees (pan troglodytes)
Drane, Aimee L.
Stöhr, Eric J.
American Association of Zoo Vetinarians
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Dependent on timing of assessment, anesthetic agents and specifically medetomidinenegatively impact cardiac function in great apes. The aim of this study was todetermine the influence of tiletamine-zolazepam with and without medetomidine oncardiac structure and function in healthy chimpanzees ( Pan troglodytes ) during aperiod of relative blood pressure stability. Twenty-four chimpanzees living in an Africanwildlife sanctuary undergoing routine health assessments were stratified by age, sexand body mass and randomized to be anesthetized using either tiletamine-zolazepam(6 mg/kg; TZ; n=13; seven males and six females) or a combination of tiletamine-zolazepam (2 mg/kg) and medetomidine (0.02 mg/kg; TZM; n= 11; five males and sixfemales). During the health checks, regular heart rate and blood pressure readingswere taken and a standardized echocardiogram was performed 20-30 minutes post-induction. Data were compared between the two anesthetic groups using independentsamples T or Mann Whitney U tests. Whileheart rate (Mean ± S.D; TZ: 76 ± 10 bpm;TZM: 65 ± 14 bpm, P = 0.027), cardiac output (TZ: 3.0 ± 0.7 L/min; TZM: 2.4 ±0.7 L/min, P = 0.032) and mitral A wave velocities (TZ: 0.51 ± 0.16 cm/s; TZM:0.36 ± 0.10 cm/s, P = 0.013) were lower in the TZM group, there were no statisticallysignificant differences in cardiac structure or the remaining functional variablesbetween groups. Furthermore, there were no statistical differences in systolic (TZ114.6 ± 14.9 mmHg; TZM: 123.0 ± 28.1 mmHg; P = 0.289) or diastolic bloodpressure (TZ: 81.8 ± 22.3 mmHg, TZM: 83.8 ± 20.1 mmHg; P = 0.827) between thegroups during the echocardiogram. This study has shown that during a period ofrelative blood pressure stability there are few differences in measures of cardiacstructure and function between protocols using tiletamine-zolazepam with or withoutmedetomidine in healthy chimpanzees.
Journal of Zoo and Wildlife Medicine;
Article accepted for publication in Journal of Zoo and Wildlife Medicine
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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