Show simple item record

dc.contributor.authorDrane, Aimee L.
dc.contributor.authorCalvi, Thalita
dc.contributor.authorFeltrer, Yedra
dc.contributor.authorCurry, Bryony
dc.contributor.authorTremblay, Joshua
dc.contributor.authorMilnes, Ellie
dc.contributor.authorStöhr, Eric J.
dc.contributor.authorHowastan, Glyn
dc.contributor.authorOxborough, David
dc.contributor.authorStembridge, Mike
dc.contributor.authorShave, Rob
dc.date.accessioned2021-04-16T11:36:29Z
dc.date.available2021-04-16T11:36:29Z
dc.date.issued2021-09-28
dc.identifier.citationDrane, A.L., Calvi, T., Feltrer, Y., Curry, B.A., Tremblay, J.C., Milnes, E.L., Stöhr, E.J., Howatson, G., Oxborough, D., Stembridge, M. and Shave, R. (2021) 'The influence of anesthesia with and without medetomidine on cardiac structure and function in sanctuary captive chimpanzees (pan troglodytes)', Journal of Zoo and Wildlife Medicine, 52(3), pp.986-996. https://doi.org/10.1638/2020-0024
dc.identifier.issn1042-7260
dc.identifier.issn1937-2825 (electronic)
dc.identifier.urihttp://hdl.handle.net/10369/11360
dc.descriptionArticle published in Journal of Zoo and Wildlife Medicine available at https://doi.org/10.1638/2020-0024en_US
dc.descriptionClosed Deposit
dc.description.abstractDependent on timing of assessment, anesthetic agents and specifically medetomidinenegatively impact cardiac function in great apes. The aim of this study was todetermine the influence of tiletamine-zolazepam with and without medetomidine oncardiac structure and function in healthy chimpanzees ( Pan troglodytes ) during aperiod of relative blood pressure stability. Twenty-four chimpanzees living in an Africanwildlife sanctuary undergoing routine health assessments were stratified by age, sexand body mass and randomized to be anesthetized using either tiletamine-zolazepam(6 mg/kg; TZ; n=13; seven males and six females) or a combination of tiletamine-zolazepam (2 mg/kg) and medetomidine (0.02 mg/kg; TZM; n= 11; five males and sixfemales). During the health checks, regular heart rate and blood pressure readingswere taken and a standardized echocardiogram was performed 20-30 minutes post-induction. Data were compared between the two anesthetic groups using independentsamples T or Mann Whitney U tests. Whileheart rate (Mean ± S.D; TZ: 76 ± 10 bpm;TZM: 65 ± 14 bpm, P = 0.027), cardiac output (TZ: 3.0 ± 0.7 L/min; TZM: 2.4 ±0.7 L/min, P = 0.032) and mitral A wave velocities (TZ: 0.51 ± 0.16 cm/s; TZM:0.36 ± 0.10 cm/s, P = 0.013) were lower in the TZM group, there were no statisticallysignificant differences in cardiac structure or the remaining functional variablesbetween groups. Furthermore, there were no statistical differences in systolic (TZ114.6 ± 14.9 mmHg; TZM: 123.0 ± 28.1 mmHg; P = 0.289) or diastolic bloodpressure (TZ: 81.8 ± 22.3 mmHg, TZM: 83.8 ± 20.1 mmHg; P = 0.827) between thegroups during the echocardiogram. This study has shown that during a period ofrelative blood pressure stability there are few differences in measures of cardiacstructure and function between protocols using tiletamine-zolazepam with or withoutmedetomidine in healthy chimpanzees.en_US
dc.language.isoenen_US
dc.publisherAmerican Association of Zoo Vetinariansen_US
dc.relation.ispartofseriesJournal of Zoo and Wildlife Medicine;
dc.titleThe influence of anesthesia with and without medetomidine on cardiac structure and function in sanctuary captive chimpanzees (pan troglodytes)en_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1638/2020-0024
dcterms.dateAccepted2021-04-07
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.refexceptionThe publication concerned actively disallows open-access deposit in a repository, and was the most appropriate publication for the output
rioxxterms.freetoread.startdate2100-01-01
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record