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dc.contributor.authorDrane, Aimee L.
dc.contributor.authorCalvi, Thalita
dc.contributor.authorFeltrer, Yedra
dc.contributor.authorCurry, Bryony
dc.contributor.authorTremblay, Joshua
dc.contributor.authorMilnes, Ellie
dc.contributor.authorStöhr, Eric J.
dc.contributor.authorHowastan, Glyn
dc.contributor.authorOxborough, David
dc.contributor.authorStembridge, Mike
dc.contributor.authorShave, Rob
dc.date.accessioned2021-04-16T11:36:29Z
dc.date.available2021-04-16T11:36:29Z
dc.date.issued2021
dc.identifier.issn1042-7260
dc.identifier.issn1937-2825 (electronic)
dc.identifier.urihttp://hdl.handle.net/10369/11360
dc.descriptionArticle accepted for publication in Journal of Zoo and Wildlife Medicineen_US
dc.descriptionClosed Deposit
dc.description.abstractDependent on timing of assessment, anesthetic agents and specifically medetomidinenegatively impact cardiac function in great apes. The aim of this study was todetermine the influence of tiletamine-zolazepam with and without medetomidine oncardiac structure and function in healthy chimpanzees ( Pan troglodytes ) during aperiod of relative blood pressure stability. Twenty-four chimpanzees living in an Africanwildlife sanctuary undergoing routine health assessments were stratified by age, sexand body mass and randomized to be anesthetized using either tiletamine-zolazepam(6 mg/kg; TZ; n=13; seven males and six females) or a combination of tiletamine-zolazepam (2 mg/kg) and medetomidine (0.02 mg/kg; TZM; n= 11; five males and sixfemales). During the health checks, regular heart rate and blood pressure readingswere taken and a standardized echocardiogram was performed 20-30 minutes post-induction. Data were compared between the two anesthetic groups using independentsamples T or Mann Whitney U tests. Whileheart rate (Mean ± S.D; TZ: 76 ± 10 bpm;TZM: 65 ± 14 bpm, P = 0.027), cardiac output (TZ: 3.0 ± 0.7 L/min; TZM: 2.4 ±0.7 L/min, P = 0.032) and mitral A wave velocities (TZ: 0.51 ± 0.16 cm/s; TZM:0.36 ± 0.10 cm/s, P = 0.013) were lower in the TZM group, there were no statisticallysignificant differences in cardiac structure or the remaining functional variablesbetween groups. Furthermore, there were no statistical differences in systolic (TZ114.6 ± 14.9 mmHg; TZM: 123.0 ± 28.1 mmHg; P = 0.289) or diastolic bloodpressure (TZ: 81.8 ± 22.3 mmHg, TZM: 83.8 ± 20.1 mmHg; P = 0.827) between thegroups during the echocardiogram. This study has shown that during a period ofrelative blood pressure stability there are few differences in measures of cardiacstructure and function between protocols using tiletamine-zolazepam with or withoutmedetomidine in healthy chimpanzees.en_US
dc.language.isoenen_US
dc.publisherAmerican Association of Zoo Vetinariansen_US
dc.relation.ispartofseriesJournal of Zoo and Wildlife Medicine;
dc.titleThe influence of anesthesia with and without medetomidine on cardiac structure and function in sanctuary captive chimpanzees (pan troglodytes)en_US
dc.typeArticleen_US
dcterms.dateAccepted2021-04-07
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.refexceptionThe publication concerned actively disallows open-access deposit in a repository, and was the most appropriate publication for the output
rioxxterms.freetoread.startdate2100-01-01
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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