The effects of low frequency electrical muscle stimulation in advanced heart failure
Cardiff Metropolitan University
MetadataDangos cofnod eitem llawn
Aims: To investigate Low Frequency Electrical Muscle Stimulation (LF-EMS) in the advanced Chronic Heart Failure (CHF) population: 1) Characterise the physiological stimulus of LF-EMS, 2) Determine the feasibility of a Randomised Controlled Trial (RCT) in the CHF population, 3) Investigate effect of LF-EMS on vascular function. Methods and Results: Study one: Nine healthy males (mean age: 24.0 ± 3.1 yrs) and 6 male patients with CHF (New York Heart Association class III- IV, mean age: 67.7 ± 14.1 yrs) undertook a 45-minute bout of LF-EMS (4Hz, continuous) of the legs. Oxygen uptake (VO2), was measured at 5-minute intervals along with multiple haemodynamic variables. VO2 increased in both groups (P<0.001), although patients with CHF demonstrated higher percentage of their maximal VO2 (5.8% [95%CI: 2.6, 7.9% :P<0.001]). Haemodynamic variables increased in both groups consistent with moderate exercise. Study two: Sixty participants with CHF were randomised to 8-weeks (5 x 60 minute per week) of LF-EMS (n=30) or ‘sham’ placebo (n=30). Recruitment, dropout and adherence were measured in addition to Six-Minute Walk Distance (6MWD) and quality of life (QoL). Sixty of 171 eligible participants (35.08%) were recruited, 12 (20%) patients withdrew. Forty-one patients (68.3%), adhered to the protocol (<70% of sessions). There were no significant differences between groups in 6MWD(P=0.13) and QoL (P=0.55). Study three: This study measured endothelial function using Flow Mediated Dilation (FMD) and maximal VO2 in a smaller cohort (LF-EMS n=20, ‘sham’ n=15). There was some evidence of enhanced FMD following LF-EMS ii compared to ‘sham’. Conclusions: Study one: LF-EMS can elicit a significantly greater cardiovascular response in patients with CHF compared to healthy individuals. Study two: People with CHF can be recruited to and tolerate LF-EMS studies; a larger RCT in this population is technically feasible. Study three: Patients with CHF using LF-EMS could gain prognostically significant improvements in endothelial function.
PhD Thesis - School of Sport and Health Sciences
Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
An assessment of food safety information provision for UK chemotherapy patients to reduce the risk of foodborne infection Evans, Ellen W.; Redmond, Elizabeth (Elsevier, 2017-08-17)Objectives: Given the increased risk of foodborne infection to cancer patients receiving chemotherapy treatment, and the risk of listeriosis reportedly five-times greater to this immunocompromised patient group, there ...
An investigation into the perioperative nutritional status of patients with oesophagogastric carcinoma and the effect of hospital food fortification and supplementary home enteral feeding on nutritional status and nutritional intake Murphy, Paula M. (Cardiff Metropolitan University, 2005)Patients who undergo surgery for upper gastrointestinal carcinoma are at high risk of inadequate nutritional intake and deterioration in nutritional status postoperatively. Early postoperative enteral feeding though widely ...
Aortic Pulse Wave Velocity as a Measure of Cardiovascular Risk in Chronic Obstructive Pulmonary Disease: Two-Year Follow-Up Data from the ARCADE Study Gale, Nichola; Albarrati, Ali; Munnery, Margaret; McDonnell, Barry; Benson, Victoria; Tal-Singer, Ruth; Cockcroft, John R.; Shale, Dennis (MDPI, 2019-04-02)Background and objectives: Cardiovascular (CV) disease is a major cause of morbidity and mortality in chronic obstructive pulmonary disease (COPD). Patients with COPD have increased arterial stiffness, which may predict ...