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dc.contributor.authorStöhr, Eric J.
dc.contributor.authorJi, Ruiping
dc.contributor.authorAkiyama, K.
dc.contributor.authorMondellini, G.
dc.contributor.authorBraghieri, L.
dc.contributor.authorPinsino, A.
dc.contributor.authorCockcroft, John R.
dc.contributor.authorYuzefpolskaya, M.
dc.contributor.authorAmlani, A.
dc.contributor.authorTopkara, V.
dc.contributor.authorTakayama, H.
dc.contributor.authorNaka, Y.
dc.contributor.authorUriel, N.
dc.contributor.authorTakeda, K.
dc.contributor.authorColombo, P.
dc.contributor.authorMcDonnell, Barry
dc.contributor.authorWilley, J.
dc.date.accessioned2021-05-17T08:30:58Z
dc.date.available2021-05-17T08:30:58Z
dc.date.issued2021-05-21
dc.identifier.citationStöhr, E.J., Ji, R., Akiyama, K., Mondellini, G., Braghieri, L., Pinsino, A., Cockcroft, J.R., Yuzefpolskaya, M., Amlani, A., Topkara, V.K. and Takayama, H., Naka, Y., Uriel, N., Takeda, K., Colombo, P., McDonnell, B. & Willey, J. (2021) 'Cerebral Vasoreactivity in HeartMate 3 Patients', The Journal of Heart and Lung Transplantation. https://doi.org/10.1016/j.healun.2021.05.005
dc.identifier.issn1053-2498
dc.identifier.urihttp://hdl.handle.net/10369/11404
dc.descriptionArticle published in Journal of Heart and Lung Transplantation available at https://doi.org/10.1016/j.healun.2021.05.005en_US
dc.description.abstractBACKGROUND: While rates of stroke have declined with the HeartMate3 (HM3) continuous flow (CF) left ventricular assist device (LVAD), the impact of non-pulsatile flow and artificial pulse physiology on cerebrovascular function is not known. We hypothesized that improved hemodynamics and artificial pulse physiology of HM3 patients would augment cerebrovascular metabolic reactivity (CVR) compared with HeartMate II (HMII) CF-LVAD and heart failure (HF) patients. METHODS: Mean, peak systolic and diastolic flow velocities (MFV, PSV, MinFV, respectively) and cerebral pulsatility index (CPI) were determined in the middle cerebral artery (MCA) before and after a 30s breath-hold challenge in 90 participants : 24 healthy controls; 30 HF, 15 HMII, and 21 HM3 patients. RESULTS: In HM3 patients, breath-holding increased MFV (Δ8±10 cm/s, P<0.0001 vs. baseline) to levels similar to HF patients (Δ9±8 cm/s, P>0.05), higher than HMII patients (Δ2±8 cm/s, P<0.01) but lower than healthy controls (Δ13±7 cm/s, P<0.05). CF-LVAD altered the proportion of systolic and diastolic flow responses as reflected by a differential CPI (P=0.03). Baseline MFV was not related to CVR (r2=0.0008, P=0.81). However, CF-LVAD pump speed was strongly inversely associated with CVR in HM II (r2=0.51, P=0.003) but not HM3 patients (r2=0.01, P=0.65). CONCLUSIONS: Compared with HMII, HM3 patients have a significantly improved CVR. However, CVR remains lower in HM3 and HF patients than in healthy controls, therefore suggesting that changes in cerebral hemodynamics are not reversed by CF-LVAD therapy. Further research on the mechanisms and the long-term impact of altered cerebral hemodynamics in this unique patient population are warranted.en_US
dc.description.sponsorshipThis project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 705219, and from the Lisa and Mark Schwartz Program to Reverse Heart Failure at New York – Presbyterian Hospital/Columbia University.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesJournal of Heart and Lung Transplantation;
dc.titleCerebral Vasoreactivity in HeartMate 3 Patientsen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.healun.2021.05.005
dcterms.dateAccepted2021-05-09
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.freetoread.startdate2022-05-21
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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