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Role of adipocyte-derived extracellular vesicles in vascular inflammation

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Author
Connolly, Katherine D.
Rees, D. Aled
James, Philip
Date
2021-05-28
Acceptance date
2021-04-23
Type
Article
Publisher
Elsevier
ISSN
0891-5849
Embargoed until
2022-05-28
Metadata
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Abstract
Extracellular vesicles (EVs) are nanometre-sized vesicles released from most cells, including adipocytes. Relatively little is known about adipocyte-derived EVs (ADEVs) in comparison to other EV subtypes, though interest in ADEVs as potential paracrine and endocrine communicators of adipose tissue in obesity is building. Current evidence indicates that ADEVs contribute to the development of adipose tissue dysfunction; a key feature of obese adipose tissue that it is associated with obesity-related comorbidities including cardiovascular disease (CVD). This review summarises our current knowledge of ADEVs in the development of adipose tissue dysfunction and the potential of ADEVs to disrupt redox signalling and exert vascular effects that may exacerbate CVD in obesity.
Journal/conference proceeding
Free Radical Biology and Medicine;
Citation
Connolly, K.D., Rees, D.A. and James, P.E. (2021) 'Role of adipocyte-derived extracellular vesicles in vascular inflammation', Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2021.04.031
URI
http://hdl.handle.net/10369/11420
DOI
https://doi.org/10.1016/j.freeradbiomed.2021.04.031
Description
Article published in Free Radical Biology and Medicine available at https://doi.org/10.1016/j.freeradbiomed.2021.04.031
Rights
http://www.rioxx.net/licenses/under-embargo-all-rights-reserved
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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