The antibacterial activity of honey against coagulase-negative staphylococci
Author
French, V.M.
Cooper, Rose
Molan, P.C.
Date
2005-07-01Publisher
Oxford Journals
ISSN
0305-7453
Metadata
Show full item recordAbstract
Objectives: Development of antibiotic-resistant strains of coagulase-negative staphylococci has complicated the management of infections associated with the use of invasive medical devices, and innovative treatment and prophylactic options are needed. Honey is increasingly being used to treat infected wounds, but little is known about its effectiveness against coagulase-negative staphylococci. The aim of this study was to determine the minimum active dilution of two standardized, representative honeys for 18 clinical isolates of coagulase-negative staphylococci.
Methods: An agar incorporation technique was used to determine the minimum active dilution, with dilution steps of 1% (v/v) honey [or steps of 5% (v/v) of a sugar syrup matching the osmotic effect of honey]. The plates were inoculated with 10 μL spots of cultures of the isolates.
Results: The honeys were inhibitory at dilutions down to 3.6 ± 0.7% (v/v) for the pasture honey, 3.4 ± 0.5% (v/v) for the manuka honey and 29.9 ± 1.9% (v/v) for the sugar syrup.
Conclusions: Typical honeys are about eight times more potent against coagulase-negative staphylococci than if bacterial inhibition were due to their osmolarity alone. Therefore, honey applied to skin at the insertion points of medical devices may have a role in the treatment or prevention of infections by coagulase-negative staphylococci.
Journal/conference proceeding
Journal of Antimicrobial Chemotherapy
Citation
French, V.M., Cooper, R.A. and Molan, P.C. (2005) 'The antibacterial activity of honey against coagulase-negative staphylococci', Journal of Antimicrobial Chemotherapy, 56(1), pp.228-231
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