Free radical production and quenching in honeys with wound healing potential
MetadataDangos cofnod eitem llawn
Objectives: Honey-impregnated wound dressings are now available on drug tariff in the UK, though the modes of action of honeys with antibacterial and wound healing properties are not entirely clear. The action of some but not all of these honeys is linked to the production of hydrogen peroxide on dilution of the honey with wound exudate. The present study investigates both free radical production and the antioxidant potential of some honeys, properties which may have a role to play in wound healing. Methods: Free radical production and quenching of three honey types (manuka, antibacterial but non-peroxide-producing; pasture, antibacterial peroxide-producing; commercial heat processed, non-antibacterial) was investigated by electron paramagnetic resonance (EPR) spectroscopy; quenching was also examined using a superoxide quenching assay. Results: All honeys tested had antioxidant potential, with manuka able to completely quench added radicals within 5 min of spiking. Only the peroxide-producing honey (pasture PS9) was found to form radicals on dilution. Conclusions: The ability to modulate production and quenching of free radicals may contribute to the demonstrated ability of some honeys to help in resolving the state of inflammation typifying chronic wounds.
Journal of Antimicrobial Chemotherapy
Henriques, A., Jackson, S., Cooper, R. and Burton, N. (2006) 'Free radical production and quenching in honeys with wound healing potential', Journal of Antimicrobial Chemotherapy, 58(4), pp.773-777
Dynodwr Gwrthrych Digidol (DOI)http://dx.doi.org/10.1093/jac/dkl336
- Un-themed 
Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
Henriques, Ana (University of Wales, 2006)Honey is an old remedy recently rediscovered as a possible alternative to modern antibiotics in wound management but its mode of action is not fully understood. The antibacterial activity of honey can be divided into ...
Al-Maaini, Rahma Ali Saleh (University of Wales, 2012)Honey has been shown to have therapeutic properties, which include immunomodulatory and antibacterial activity in vitro and anti-inflammatory, antipyretic and wound healing properties in vivo. A complex mix of factors ...
The role of Manuka honey in wound healing and inflammation using IL-6 and human dermal fibroblasts as model systems Kulakova, Elizaveta (Cardiff Metropolitan University, 2017-06-01)Introduction In the past, clinical trials have shown that honey helps to accelerate the healing process of chronic wounds due to its antibacterial and anti-inflammatory properties. Over the increasing concern raised ...