Free radical production and quenching in honeys with wound healing potential
Awdur
Henriques, Ana
Jackson, S.
Cooper, Rose
Burton, Neil
Dyddiad
2006-10-01Cyhoeddwr
Oxford Journals
ISSN
0305-7453
Metadata
Dangos cofnod eitem llawnCrynodeb
Objectives: Honey-impregnated wound dressings are now available on drug tariff in the UK, though the modes of action of honeys with antibacterial and wound healing properties are not entirely clear. The action of some but not all of these honeys is linked to the production of hydrogen peroxide on dilution of the honey with wound exudate. The present study investigates both free radical production and the antioxidant potential of some honeys, properties which may have a role to play in wound healing.
Methods: Free radical production and quenching of three honey types (manuka, antibacterial but non-peroxide-producing; pasture, antibacterial peroxide-producing; commercial heat processed, non-antibacterial) was investigated by electron paramagnetic resonance (EPR) spectroscopy; quenching was also examined using a superoxide quenching assay.
Results: All honeys tested had antioxidant potential, with manuka able to completely quench added radicals within 5 min of spiking. Only the peroxide-producing honey (pasture PS9) was found to form radicals on dilution.
Conclusions: The ability to modulate production and quenching of free radicals may contribute to the demonstrated ability of some honeys to help in resolving the state of inflammation typifying chronic wounds.
Cyfnodolyn/trafodion cynhadledd
Journal of Antimicrobial Chemotherapy
Dyfyniad
Henriques, A., Jackson, S., Cooper, R. and Burton, N. (2006) 'Free radical production and quenching in honeys with wound healing potential', Journal of Antimicrobial Chemotherapy, 58(4), pp.773-777
Dynodwr Gwrthrych Digidol (DOI)
http://dx.doi.org/10.1093/jac/dkl336Casgliadau
- Un-themed [116]
Eitemau perthynol
Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
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The Antibacterial Activity of Honey
Henriques, Ana (University of Wales, 2006)Honey is an old remedy recently rediscovered as a possible alternative to modern antibiotics in wound management but its mode of action is not fully understood. The antibacterial activity of honey can be divided into ... -
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Al-Maaini, Rahma Ali Saleh (University of Wales, 2012)Honey has been shown to have therapeutic properties, which include immunomodulatory and antibacterial activity in vitro and anti-inflammatory, antipyretic and wound healing properties in vivo. A complex mix of factors ... -
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Otman, Fatma (Cardiff Metropolitan University, 2010)Honey has been utilized since ancient times for the management of different types of wounds. Only a few studies have been performed to explore which active components of Manuka honey cause the stimulation of production of ...