Comparison of Parameters betweeen the IL GEM 4000 Blood Gas Analyser and the Abbott Architect ci8200
University of Wales Institute Cardiff
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Introduction: This study aims to seek comparability between results given by the IL GEM Premier 4000 blood gas analyser and Abbott Architect ci8200 laboratory analyser. It is vital for the continuity of care and patient safety that results given by these point of care testing (POCT) analysers are comparable to those given by the laboratory. Materials and Methods: In this study, glucose and potassium methods were compared and statically analysed using Least Squares linear regression analysis, paired t-tests and Altman-Bland plots. 56 samples were collected for potassium comparison, and 69 samples were collected for glucose comparison. The accuracy and precision of these methods were also evaluated. In addition, haemolysis indices of the potassium samples were determined. Results: Out of the 69 glucose samples analysed, there was no significant difference in the mean values between the IL GEM Premier 4000 and Abbott Architect ci8200 (7.8 ± 4.2 mmol/l vs. 7.4 ± 4.2 mmol/l, P <0.001). The potassium methods compared similarly, out of the 56 samples analysed, there was no significant difference in the mean values between the analysers (3.8 ± 0.7 mmol/l vs. 3.9 ± 0.7 mmol/l, P < 0.001). 1 of the 56 samples was found to have a haemolysis index above the accepted level of 1.5g/l, and therefore would have not been reported by the Abbott Architect ci8200.  Glucose and potassium methods of both analysers performed at an acceptable level of precision and accuracy. The overall biases for both methods on both analysers were < 1.0 %, well within the accepted limit of +/- 5.0 %. Levels of precision were just as satisfactory; with % CV’s for both analysers for both methods being ≤ 2.71 %. Discussion: It is important to take away from this study that although POCT devices can correlate well with the laboratory, not every POCT device on the market will do this, and before a POCT device is implemented, its methods must be deemed robust, accurate and precise, and fit for purpose.
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