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dc.contributor.authorSwampillai, J.en_UK
dc.contributor.authorRakebrandt, F.en_UK
dc.contributor.authorMorris, Keith
dc.contributor.authorJones, C.
dc.contributor.authorFraser, A.G.
dc.identifier.citationSwampillai, J., Rakebrandt, F., Morris, K., Jones, C.J.H. and Fraser, A.G. (2006) 'Acute effects of caffeine and tobacco on arterial function and wave travel', European Journal of Clinical Investigation, 36(12), pp.844-849.en_UK
dc.descriptionThis article was published in European Journal of Clinical Investigation on 7 November 2006 (online), available at
dc.description.abstractBackground  Caffeine and tobacco consumption are risk factors for heart failure, but their effects remain controversial. It has been hypothesized that they cause alterations in arterial stiffness and arterial wave travel which may increase ventricular loading. In this study the authors examined the influence of these widely used stimulants on wave intensity and arterial stiffness parameters using carotid wave intensity analysis. Materials and methods  A new Doppler-based ultrasound method was used to measure the acute effects of caffeine and tobacco on wave intensity in the right common carotid artery. The measurements enabled changes in arterial stiffness parameters to be recorded. Results  In 17 subjects compared with 10 controls, caffeine increased blood pressure, early systolic wave intensity and wave speed, but late-systolic wave intensity and mid-systolic reflections were unchanged. In 11 smokers studied before and after smoking one cigarette, blood pressure and arterial stiffness increased but wave intensity was unchanged. No changes were observed in the controls. Conclusions  Increased wave intensity during ejection after caffeine suggested sympathomimetic effects on the left ventricular function. Increased wave speed in the common carotid artery implied augmented central loading after caffeine, but the absence of measurable changes in local arterial stiffness in the carotid artery suggested more complex and regional effects. Cigarette smoking acutely increased local arterial stiffness in the common carotid artery. These changes can be detected using wave intensity analysis
dc.publisherWiley-Blackwell Publishing Ltd.en_UK
dc.relation.ispartofseriesEuropean Journal of Clinical Investigationen_UK
dc.subjectarterial haemodynamics
dc.subjectarterial stiffness
dc.subjectarterial wave travel
dc.subjectwave intensity
dc.titleAcute effects of caffeine and tobacco on arterial function and wave travelen_UK

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