Show simple item record

dc.contributor.authorBolton, C.E.en
dc.contributor.authorEvans, M.en
dc.contributor.authorIonescu, A.A.en
dc.contributor.authorEdwards, S.M.
dc.contributor.authorMorris, Keith
dc.contributor.authorDunseath, G.
dc.contributor.authorLuzio, S,D.
dc.contributor.authorOwens, D.R.
dc.contributor.authorShale, D.J.
dc.date.accessioned2008-10-17T11:25:39Z
dc.date.available2008-10-17T11:25:39Z
dc.date.issued2007en
dc.identifier.citationBolton, C.E., Evans, M., Ionescu, A.A., Edwards, S.M., Morris, R.H.K., Dunseath, G., Luzio, S.D., Owens, D.R. and Shale, D.J. (2007) 'Insulin resistance and inflammation—a further systemic complication of COPD', COPD: Journal of Chronic Obstructive Pulmonary Disease, 4(2), pp.121-126.en
dc.identifier.issn1254-2555en
dc.identifier.urihttp://hdl.handle.net/10369/367
dc.descriptionThis article was published in COPD: Journal of Chronic Obstructive Pulmonary Disease on 02 July 2009 (online), available at http://dx.doi.org/10.1080/15412550701341053
dc.description.abstractChronic obstructive pulmonary disease (COPD) is associated with a continuous systemic inflammatory response. Furthermore, COPD is associated with an excess risk for cardiovascular disease and type II diabetes. Systemic inflammation in other populations is a factor in atherogenesis and has been associated with insulin resistance. We assessed the association between systemic inflammation and insulin resistance in non-hypoxaemic patients with COPD. Fasting plasma glucose, insulin and inflammatory mediators were measured in 56 patients and 29 healthy subjects. Body mass index (BMI) and height squared fat- and fat-free-mass index were similar between subject groups. Using homeostatic modelling techniques, mean (SD) insulin resistance was greater in the patients, 1.68 (2.58) and 1.13 (2.02) in healthy subjects, p= 0.032. Fasting plasma insulin was increased in patients while glucose was similar to that in healthy subjects. Patients had increased circulating inflammatory mediators. Insulin resistance was related to interleukin-6 (IL-6), r = 0.276, p= 0.039, and tumour necrosis factor a soluble receptor I, r = 0.351, p= 0.008. Both IL-6 and BMI were predictive variables of insulin resistance r2 = 0.288, p <0.05. We demonstrated greater insulin resistance in non-hypoxaemic patients with COPD compared with healthy subjects, which was related to systemic inflammation. This relationship may indicate a contributory factor in the excess risk of cardiovascular disease and type II diabetes in COPD.en
dc.description.urihttp://dx.doi.org/10.1080/15412550701341053
dc.publisherInforma Healthcareen
dc.relation.ispartofseriesCOPD: Journal of Chronic Obstructive Pulmonary Diseaseen
dc.titleInsulin resistance and inflammation — a further systemic complication of COPDen
dc.identifier.doihttp://dx.doi.org/10.1080/15412550701341053


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following collection(s)

Show simple item record