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The influence of the Pro12Ala mutation of the PPAR-gamma receptor gene on metabolic and clinical characteristics in treatment-naive patients with type 2 diabetes

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Author
Ahluwalia, Maninder
Evans, M.
Morris, Keith
Currie, C.
Davies, S.
Rees, A.
Thomas, Andrew
Date
2002-11-01
Publisher
Wiley-Blackwell Publishing Ltd
ISSN
14631326
Metadata
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Abstract
Peroxisome proliferator activated receptor-gamma is an important factor in adipocyte differentiation and energy metabolism and is thus a candidate gene for obesity, insulin resistance and dyslipidaemia. We therefore assessed the associations between the most common variant of the PPAR-gamma, the Pro12Ala (P12A) substitution in the PPAR-gamma 2 gene, with BMI, blood pressure, fasting plasma glucose, HbA1c, total cholesterol, LDL and HDL cholesterol and plasma triglyceride in 183 treatment-naïve patients with type 2 diabetes (T2D). The P12A allele associated with lower fasting plasma glucose but had no influence on HbA1c or BMI. In obese patients (BMI > 29 kg/m2), the P12A substitution associated with elevated total and non-HDL cholesterol levels.
Journal/conference proceeding
Diabetes Obesity and Metabolism
Citation
Ahluwalia, M., Evans, M., Morris, K., Currie, C., Davies, S., Rees, A. and Thomas, A. (2002) 'The influence of the Pro12Ala mutation of the PPAR‐gamma receptor gene on metabolic and clinical characteristics in treatment‐naïve patients with type 2 diabetes', Diabetes, Obesity and Metabolism, 4(6), pp.376-378.
URI
http://hdl.handle.net/10369/403
DOI
http://dx.doi.org/10.1046/j.1463-1326.2002.00230.x
Description
This article was published in Diabetes Obesity and Metabolism on 30 October 2002 (online), available at http://dx.doi.org/10.1046/j.1463-1326.2002.00230.x
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