The influence of the Pro12Ala mutation of the PPAR-gamma receptor gene on metabolic and clinical characteristics in treatment-naive patients with type 2 diabetes
Wiley-Blackwell Publishing Ltd
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Peroxisome proliferator activated receptor-gamma is an important factor in adipocyte differentiation and energy metabolism and is thus a candidate gene for obesity, insulin resistance and dyslipidaemia. We therefore assessed the associations between the most common variant of the PPAR-gamma, the Pro12Ala (P12A) substitution in the PPAR-gamma 2 gene, with BMI, blood pressure, fasting plasma glucose, HbA1c, total cholesterol, LDL and HDL cholesterol and plasma triglyceride in 183 treatment-naïve patients with type 2 diabetes (T2D). The P12A allele associated with lower fasting plasma glucose but had no influence on HbA1c or BMI. In obese patients (BMI > 29 kg/m2), the P12A substitution associated with elevated total and non-HDL cholesterol levels.
Diabetes Obesity and Metabolism
Ahluwalia, M., Evans, M., Morris, K., Currie, C., Davies, S., Rees, A. and Thomas, A. (2002) 'The influence of the Pro12Ala mutation of the PPAR‐gamma receptor gene on metabolic and clinical characteristics in treatment‐naïve patients with type 2 diabetes', Diabetes, Obesity and Metabolism, 4(6), pp.376-378.
This article was published in Diabetes Obesity and Metabolism on 30 October 2002 (online), available at http://dx.doi.org/10.1046/j.1463-1326.2002.00230.x