Show simple item record

dc.contributor.authorEvans, M.
dc.contributor.authorAnderson, R.A.
dc.contributor.authorSmith, J.C.
dc.contributor.authorKhan, N.
dc.contributor.authorGraham, J.M.
dc.contributor.authorThomas, Andrew
dc.contributor.authorMorris, Keith
dc.contributor.authorDeely, D.
dc.contributor.authorFrenneaux, M.P.
dc.contributor.authorDavies, J.S.
dc.contributor.authorRees, A.
dc.date.accessioned2008-10-17T11:25:44Z
dc.date.available2008-10-17T11:25:44Z
dc.date.issued2003-03-01en_US
dc.identifier.citationEvans, M., Anderson, R.A., Smith, J.C., Khan, N., Graham, J.M., Thomas, A.W., Morris, K., Deely, D., Frenneaux, M.P., Davies, J.S. and Rees, A. (2003) 'Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus', European Journal of Clinical Investigation, 33(3), pp.231-238en_US
dc.identifier.issn1365-2362
dc.identifier.urihttp://hdl.handle.net/10369/405
dc.description.abstractBACKGROUND: Insulin therapy may influence cardiovascular disease (CVD) and lipid metabolism in type 2 diabetes (T2D). Exaggerated postprandial lipaemia (PPL) is a feature of diabetic dyslipidaemia affecting CVD via enhanced oxidative stress (OS) and endothelial dysfunction. We assessed endothelial function and OS during PPL following insulin and vitamin C. Twenty (17 M) T2D patients were studied (mean Hba1c 8.4%) at baseline, following 6 weeks of insulin lispro (0.2 Iu kg-1) and vitamin C 1-g daily. Eight-h lipid and glucose profiles were measured following a fatty meal. Endothelial function (flow-mediated vasodilatation: FMD) and OS were measured at fasting, 4 h and 8 h. MATERIALS AND METHODS: Glucose, body mass index, and total and LDL cholesterol remained unchanged. FMD improved. Placebo group: fasting, 1.1 +/- 1.2 to 4.2 +/- 1.1% (P < 0.001); 4-h, 0.3 +/- 1.2 to 3.1 +/- 0.9% (P < 0.01); 8-h, 0.7 +/- 1.1 to 3.76 +/- 1.1% (P < 0.001). Vitamin C group: fasting, 0.9 +/- 1.1 to 6.1 +/- 1.3% (P < 0.001); 4-h, 0.7 +/- 1.5 to 4.9 +/- 2.1% (P < 0.001); 8-h, 0.8 +/- 0.9 to 5.8 +/- 0.6% (P < 0.01). Post-prandial lipaemia was attenuated: TG area-under-curve (mmol L-1 8 h-1), 52.6 +/- 11 to 39.1 +/- 12.5 (placebo group), P < 0.02; and 56.9 +/- 8 to 40.1 +/- 10.3 (vitamin C group), P < 0.02. Oxidative stress was reduced, with greater changes in the vitamin C group. CONCLUSION: Insulin may thus exert vascular benefits in T2D, by modifying fasting and postprandial lipid metabolism resulting in reduced OS and improved EF. Vitamin C therapy may augment the vascular benefits of insulin in T2D through additional effects on OS and EF.en
dc.publisherWiley-Blackwell Publishing Ltd.en_US
dc.relation.ispartofseriesEuropean Journal of Clinical Investigationen
dc.titleEffects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitusen_US
dc.identifier.doihttp://dx.doi.org/10.1046/j.1365-2362.2003.01120.xen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following collection(s)

Show simple item record