Exercise-induced cardiac troponin release: real-life clinical confusion
Author
Eijsvogels, Thijs
Shave, Rob
van Dijk, A.
Hopman, Maria T.E.
Thijssen, D.H.J.
Date
2011Type
Article
ISSN
0929-8673
Metadata
Show full item recordAbstract
Exercise training represents a successful and powerful strategy to prevent future cardiovascular disease. Paradoxically, performance of exercise is also associated with an increased risk of acute cardiac events. Accordingly, patients may present to hospital with cardiac symptoms following a bout of unaccustomed physical effort (e.g. exercise). Current guidelines for the identification of an acute myocardial infarction (AMI) importantly depend on the presence of cardiac troponin as a highly sensitive marker of cardiac damage. However, a number of studies have reported elevated cardiac troponin levels in asymptomatic, healthy subjects after endurance exercise (such as a marathon, prolonged cycling or prolonged walking). These observations indicate that elevated cardiac troponin levels can be the result of cardiac ischemia, and subsequent necrosis, but also may be related to strenuous exercise. In this paper, we present three different clinical cases of post-exercise elevations in cardiac troponins, each with a distinct clinical presentation. These case studies emphasize that a detailed assessment of all symptoms and a thorough patient-history are prerequisite for accurate interpretation of a positive cardiac troponin test following exercise.
Journal/conference proceeding
Current Medical Chemistry
Citation
MH Eijsvogels, T., Shave, R., van Dijk, A., TE Hopman, M. and HJ Thijssen, D. (2011) 'Exercise-induced cardiac troponin release: real-life clinical confusion', Current medicinal chemistry, 18(23), pp.3457-3461
Collections
- Sport Research Groups [1088]
Related items
Showing items related by title, author, subject and abstract.
-
Exercise-associated increases in cardiac biomarkers
Scharhag, Jurgen; George, Keith; Shave, Rob; Urhausen, Axel; Kindermann, Wilfried (2008)At present, the risk of myocardial damage by endurance exercise is under debate because of reports on exercise-associated increases in cardiac biomarkers troponin and B-type natriuretic peptide (BNP); these markers are ... -
Cardiac troponin I is released following highintensity short-duration exercise in healthy humans.
Shave, Rob; Ross, Peter; Low, David A.; George, Keith; Gaze, David (2010)It has been previously shown that cardiac troponin (cTn) is released in response to prolonged endurance exercise. The influence of short-duration high-intensity exercise upon the release of cTn is not known. We examined ... -
The impact of exercise duration and intensity on the release of cardiac biomarkers
Serrano-Ostariz, E.; Terreros-Blanco, J.L.; Legaz-Arrese, A.; George, Keith; Shave, Rob; Bocos-Terraz, P.; Izquierdo-Alvarez, S.; Bancalero, J.L.; Echavarri, J.M.; Quilez, J.; Carranza-Garcia, L.E.; Aragones, M.T. (2009)Numerous studies have observed cardiac biomarker release with prolonged exercise. Despite this, we are unsure as to the constituent aspects of any given exercise bout that may be important in promoting cardiac biomarker ...