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dc.contributor.authorStöhr, Eric J.
dc.contributor.authorGonzalez-Alonso, Jose
dc.contributor.authorPearson, James
dc.contributor.authorLow, David A.
dc.contributor.authorAli, Leena
dc.contributor.authorBarker, Horace
dc.contributor.authorShave, Rob
dc.identifier.citationStöhr, E.J., González-Alonso, J., Pearson, J., Low, D.A., Ali, L., Barker, H. and Shave, R., (2011) 'Dehydration reduces left ventricular filling at rest and during exercise independent of twist mechanics', Journal of Applied Physiology, 111(3), pp.891-897.en_US
dc.descriptionThis article was published in Journal of Applied Physiology on 1 September 2011 (online), available at
dc.description.abstractThe purpose of this study was to determine whether the reduction in stroke volume (SV), previously shown to occur with dehydration and increases in internal body temperatures during prolonged exercise, is caused by a reduction in left ventricular (LV) function, as indicated by LV volumes, strain, and twist (“LV mechanics”). Eight healthy men [age: 20 ± 2, maximal oxygen uptake (VO2max): 58 ± 7 ml·kg−1·min−1] completed two, 1-h bouts of cycling in the heat (35°C, 50% peak power) without fluid replacement, resulting in 2% and 3.5% dehydration, respectively. Conventional and two-dimensional speckle-tracking echocardiography was used to determine LV volumes, strain, and twist at rest and during one-legged knee-extensor exercise at baseline, both levels of dehydration, and following rehydration. Progressive dehydration caused a significant reduction in end-diastolic volume (EDV) and SV at rest and during one-legged knee-extensor exercise (rest: Δ − 33 ± 14 and Δ − 21 ± 14 ml, respectively; exercise: Δ − 30 ± 10 and Δ − 22 ± 9 ml, respectively, during 3.5% dehydration). In contrast to the marked decline in EDV and SV, systolic and diastolic LV mechanics were either maintained or even enhanced with dehydration at rest and during knee-extensor exercise. We conclude that dehydration-induced reductions in SV at rest and during exercise are the result of reduced LV filling, as reflected by the decline in EDV. The concomitant maintenance of LV mechanics suggests that the decrease in LV filling, and consequently ejection, is likely caused by the reduction in blood volume and/or diminished filling time rather than impaired LV function.
dc.publisherAmerican Physiological Society
dc.relation.ispartofseriesJournal of Applied Physiology
dc.titleDehydration reduces left ventricular filling at rest and during exercise independent of twist mechanicsen_US

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