Exercise-induced cardiac troponin elevation: evidence, mechanisms, and implications
Thompson, Paul D.
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Regular physical exercise is recommended for the primary prevention of cardiovascular disease. Although the high prevalence of physical inactivity remains a formidable public health issue, participation in exercise programs and recreational sporting events, such as marathons and triathlons, is on the rise. Although regular exercise training reduces cardiovascular disease risk, recent studies have documented elevations in cardiac troponin (cTn) consistent with cardiac damage after bouts of exercise in apparently healthy individuals. At present, the prevalence, mechanism(s), and clinical significance of exercise-induced cTn release remains incompletely understood. This paper will review the biochemistry, prevalence, potential mechanisms, and management of patients with exercise-induced cTn elevations.
Journal of the American College of Cardiology;
Shave, R., Baggish, A., George, K., Wood, M., Scharhag, J., Whyte, G., Gaze, D. and Thompson, P.D. (2010) 'Exercise-induced cardiac troponin elevation: evidence, mechanisms, and implications', Journal of the American College of Cardiology, 56(3), pp.169-176
Dynodwr Gwrthrych Digidol (DOI)http://dx.doi.org/10.1016/j.jacc.2010.03.037
- Sport Research Groups 
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Eijsvogels, Thijs; Shave, Rob; van Dijk, A.; Hopman, Maria T.E.; Thijssen, D.H.J. (2011)Exercise training represents a successful and powerful strategy to prevent future cardiovascular disease. Paradoxically, performance of exercise is also associated with an increased risk of acute cardiac events. Accordingly, ...
Scharhag, Jurgen; George, Keith; Shave, Rob; Urhausen, Axel; Kindermann, Wilfried (2008)At present, the risk of myocardial damage by endurance exercise is under debate because of reports on exercise-associated increases in cardiac biomarkers troponin and B-type natriuretic peptide (BNP); these markers are ...
Serrano-Ostariz, E.; Terreros-Blanco, J.L.; Legaz-Arrese, A.; George, Keith; Shave, Rob; Bocos-Terraz, P.; Izquierdo-Alvarez, S.; Bancalero, J.L.; Echavarri, J.M.; Quilez, J.; Carranza-Garcia, L.E.; Aragones, M.T. (2009)Numerous studies have observed cardiac biomarker release with prolonged exercise. Despite this, we are unsure as to the constituent aspects of any given exercise bout that may be important in promoting cardiac biomarker ...