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Cardiorespiratory and cerebrovascular responses to head-up tilt II: influence of age, training status and acute exercise

Thumbnail
Author
Murrell, Carissa J.
Cotter, James D.
George, Keith
Shave, Rob
Wilson, Luke
Thomas, Kate
Williams, Michael J.
Ainslie, Philip N.
Date
2011
Type
Article
Publisher
Elsevier
ISSN
0531-5565
Metadata
Show full item record
Abstract
The purpose of this study was to examine the combined cardiorespiratory and cerebrovascular responses to head-up tilt (HUT) in young and older trained and untrained humans following moderate-duration exercise. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finometer), and stroke volume (SV) were measured continuously whilst supine and during 60° HUT for 15 min or to pre-syncope in 41 participants [nine young trained; eleven young untrained; twelve older trained; nine older untrained] prior to and following 30 min of treadmill exercise at 70–80% maximal HR. Orthostatic tolerance was not reduced following exercise [Mean (all groups) 14:45 ± 1:19, vs. 14:47 ± 0:43 min:s (before exercise); P = 0.73], and did not differ with age or fitness. Mean MCAv was elevated [~ 5 ± 11%] whilst supine after exercise in the older participants but reduced [~−4 ± 12%] in the young [P = 0.03]. The postural reductions in MCAv [~−22% vs. –17%; P = 0.02], MAP [~−8% vs. −3%; P = 0.04] and SV [~−28% vs. −23%; P = 0.03] were increased after exercise (vs. pre-exercise). Orthostatic tolerance was not reduced following 30 min of exercise, and did not differ with age or fitness, despite more pronounced post-exercise reductions in MCAv, MAP and SV with postural ch
Journal/conference proceeding
Experimental Gerontology
Citation
Murrell, C.J., Cotter, J.D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M.J. and Ainslie, P.N. (2011) 'Cardiorespiratory and cerebrovascular responses to head-up tilt II: influence of age, training status and acute exercise', Experimental Gerontology, 46(1), pp.1-8
URI
http://hdl.handle.net/10369/4393
DOI
http://dx.doi.org/10.1016/j.exger.2010.06.004
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