Cardiorespiratory and cerebrovascular responses to head-up tilt II: influence of age, training status and acute exercise
Murrell, Carissa J.
Cotter, James D.
Williams, Michael J.
Ainslie, Philip N.
MetadataShow full item record
The purpose of this study was to examine the combined cardiorespiratory and cerebrovascular responses to head-up tilt (HUT) in young and older trained and untrained humans following moderate-duration exercise. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finometer), and stroke volume (SV) were measured continuously whilst supine and during 60° HUT for 15 min or to pre-syncope in 41 participants [nine young trained; eleven young untrained; twelve older trained; nine older untrained] prior to and following 30 min of treadmill exercise at 70–80% maximal HR. Orthostatic tolerance was not reduced following exercise [Mean (all groups) 14:45 ± 1:19, vs. 14:47 ± 0:43 min:s (before exercise); P = 0.73], and did not differ with age or fitness. Mean MCAv was elevated [~ 5 ± 11%] whilst supine after exercise in the older participants but reduced [~−4 ± 12%] in the young [P = 0.03]. The postural reductions in MCAv [~−22% vs. –17%; P = 0.02], MAP [~−8% vs. −3%; P = 0.04] and SV [~−28% vs. −23%; P = 0.03] were increased after exercise (vs. pre-exercise). Orthostatic tolerance was not reduced following 30 min of exercise, and did not differ with age or fitness, despite more pronounced post-exercise reductions in MCAv, MAP and SV with postural ch
Murrell, C.J., Cotter, J.D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M.J. and Ainslie, P.N. (2011) 'Cardiorespiratory and cerebrovascular responses to head-up tilt II: influence of age, training status and acute exercise', Experimental Gerontology, 46(1), pp.1-8
- Sport Research Groups 
Showing items related by title, author, subject and abstract.
Lane, Sophie (Cardiff Metropolitan University, 2015)Introduction: High blood pressure has been identified to largely contribute to cardiovascular disease. Regular exercise has been prescribed by medical organisations as a strategy to treat and prevent high blood pressure. ...
AMPK inactivation in mononuclear cells: a potential intracellular mechanism for exercise-induced immunosuppression Moir, Hannah; Butcher, Lee; Jones, Ken; Hughes, Michael G.; Neale, Huw; Jia, Huidong; Al-Ismaily, Zuleikha; Webb, Richard (NRC Research Press, 2008)There is much evidence that prolonged intense exercise suppresses the immune system. However, the intracellular biochemical mechanisms linking exercise and immunosuppression remain obscure. The purpose of this study was ...
Exercise-associated generation of PPARγ ligands activates PPARγ signaling events and upregulates genes related to lipid metabolism Thomas, A. W.; Davies, N. A.; Moir, H.; Watkeys, L.; Ruffino, J. S.; Isa, S. A.; Butcher, L. R.; Hughes, M. G.; Morris, K.; Webb, Richard (American Physiological Society, 2012)The aim of the present study was to test the hypotheses that exercise is associated with generation of peroxisome proliferator-activated receptor-γ (PPARγ) ligands in the plasma and that this may activate PPARγ signaling ...