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dc.contributor.authorMurrell, Carissa J.
dc.contributor.authorCotter, James D.
dc.contributor.authorGeorge, Keith
dc.contributor.authorShave, Rob
dc.contributor.authorWilson, Luke
dc.contributor.authorThomas, Kate
dc.contributor.authorWilliams, Michael J.
dc.contributor.authorAinslie, Philip N.
dc.date.accessioned2013-07-04T07:31:59Z
dc.date.available2013-07-04T07:31:59Z
dc.date.issued2011
dc.identifier.citationMurrell, C.J., Cotter, J.D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M.J. and Ainslie, P.N. (2011) 'Cardiorespiratory and cerebrovascular responses to head-up tilt II: influence of age, training status and acute exercise', Experimental Gerontology, 46(1), pp.1-8en_US
dc.identifier.issn0531-5565
dc.identifier.urihttp://hdl.handle.net/10369/4393
dc.description.abstractThe purpose of this study was to examine the combined cardiorespiratory and cerebrovascular responses to head-up tilt (HUT) in young and older trained and untrained humans following moderate-duration exercise. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finometer), and stroke volume (SV) were measured continuously whilst supine and during 60° HUT for 15 min or to pre-syncope in 41 participants [nine young trained; eleven young untrained; twelve older trained; nine older untrained] prior to and following 30 min of treadmill exercise at 70–80% maximal HR. Orthostatic tolerance was not reduced following exercise [Mean (all groups) 14:45 ± 1:19, vs. 14:47 ± 0:43 min:s (before exercise); P = 0.73], and did not differ with age or fitness. Mean MCAv was elevated [~ 5 ± 11%] whilst supine after exercise in the older participants but reduced [~−4 ± 12%] in the young [P = 0.03]. The postural reductions in MCAv [~−22% vs. –17%; P = 0.02], MAP [~−8% vs. −3%; P = 0.04] and SV [~−28% vs. −23%; P = 0.03] were increased after exercise (vs. pre-exercise). Orthostatic tolerance was not reduced following 30 min of exercise, and did not differ with age or fitness, despite more pronounced post-exercise reductions in MCAv, MAP and SV with postural ch
dc.language.isoenen_US
dc.publisherElsevier
dc.relation.ispartofseriesExperimental Gerontology
dc.titleCardiorespiratory and cerebrovascular responses to head-up tilt II: influence of age, training status and acute exerciseen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.exger.2010.06.004


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