A depression in left ventricular diastolic filling following prolonged strenuous exercise is associated with changes in left atrial mechanics
MetadataShow full item record
Background Standard marathon running can result in a depression of left ventricular (LV) diastolic function during early recovery. Left atrial (LA) mechanics are integral in maintaining an early diastolic pressure gradient as well as being responsive to changes in LV diastolic function, and therefore the detailed assessment of LA mechanics may provide further insight. The aim of this study was to determine the impact of prolonged strenuous exercise on mechanics of the left atrium and the association with changes in LV diastolic function. Methods Myocardial speckle-tracking echocardiograms of the left atrium and left ventricle were obtained prior to, immediately after, and 6 hours after the completion of a marathon (42.2 km) in 17 healthy adult men. Speckle tracking was used to determine peak atrial deformation, early diastolic deformation rate, and contractile function, including atrial activation time. LA volumes throughout the cardiac cycle were also assessed to provide reservoir, conduit, and booster pump volumes. Diastolic assessment of the left ventricle included peak early diastolic strain rate, late diastolic strain rate, and standard indices. Temporal assessment of LV “twist” and “untwist” was also evaluated. Results All 17 subjects completed the marathon (mean finishing time, 209 ± 19 minutes; range, 173-241 minutes). Although contractile function was significantly increased, there was a reduction in early diastolic deformation rate that was correlated with reduced atrial deformation. Atrial activation time was significantly increased after the race. All LV indices of diastolic function were reduced in early diastole, whereas late diastolic function was increased after the race. LV torsion was significantly reduced at end-systole and significantly elevated in the isovolumic period and early diastole, after the race. All indices returned toward baseline at 6 hours after exercise. Conclusions This study demonstrates transient changes in LV diastolic relaxation following prolonged exercise that appear to have a direct impact on subsequent LA deformation. The impact of reduced LA preload on these findings and the delay in LA activation time requires further exploration.
Journal of the American Society of Echocardiography
Oxborough, D., Whyte, G., Wilson, M., O'hanlon, R., Birch, K., Shave, R., Smith, G., Godfrey, R., Prasad, S. and George, K. (2010) 'A depression in left ventricular diastolic filling following prolonged strenuous exercise is associated with changes in left atrial mechanics', Journal of the American Society of Echocardiography, 23(9), pp.968-976.
- Sport Research Groups 
Showing items related by title, author, subject and abstract.
Age‐related changes to cardiac systolic and diastolic function during whole‐body passive hyperthermia Lucas, Rebekah; Sarma, Satyam; Schadler, Zachary; Pearson, James; Crandall, Craig (Wiley, 2015-01-15)The effect of ageing on hyperthermia‐induced changes in cardiac function is unknown. This study tested the hypothesis that hyperthermia‐induced changes in left ventricular systolic and diastolic function are attenuated in ...
Left ventricular wall segment motion after ultra-endurance exercise in humans assessed by myocardial speckle tracking George, Keith; Shave, Rob; Oxborough, David; Cable, Tim; Dawson, Ellen; Artis, Nigel; Gaze, David; Hew-Butler, Tamara; Sharwood, Karen; Noakes, Tim (2009)Aims Assessment of the left ventricular responses to prolonged exercise has been limited by technology available to assess cardiac tissue movement. Recently developed strain and strain rate imaging provide the unique ...
Impaired myocardial function does not explain reduced left ventricular filling and stroke volume at rest or during exercise at high altitude Stembridge, Mike; Ainslie, Philip; Hughes, Michael G.; Stöhr, Eric J.; Cotter, James D.; Tymko, Michael M.; Day, Trevor A.; Bakker, Akke; Shave, Rob (American Physiological Society, 2015-11-15)Impaired myocardial systolic contraction and diastolic relaxation have been suggested as possible mechanisms contributing to the decreased stroke volume (SV) observed at high altitude (HA). To determine whether intrinsic ...