Diastolic function in healthy humans: non-invasive assessment and the impact of acute and chronic exercise
Author
George, Keith
Naylor, Louise H.
Whyte, Greg
Shave, Rob
Oxborough, David
Green, Daniel J.
Date
2010Type
Article
ISSN
1439-6319
Metadata
Show full item recordAbstract
Left ventricular (LV) diastolic function is important because the enhanced systolic function that underpins high levels of cardio-respiratory fitness has to be matched by changes in LV filling, and LV diastolic dysfunction plays a key early role in the development and progression of a myriad of cardiovascular diseases. This review serves to detail knowledge in relation to: (1) the definition of diastole and the mechanical processes that occur during the diastolic period, (2) the quantitative assessment of diastolic function, predominantly focusing on non-invasive echocardiographic imaging modes such as tissue Doppler imaging and deformation analysis, (3) the impact of acute aerobic exercise on diastolic function, from the augmentation of function necessary to meet the demand for an increased cardiac output at exercise onset, to current concerns related to the impact of prolonged or ultra-endurance activity on diastolic function during recovery, (4) the adaptation in diastolic function observed with chronic aerobic exercise training in athletes and sedentary individuals who undergo training programmes, and (5) directions for future research.
Journal/conference proceeding
European Journal of Applied Physiology
Citation
George, K.P., Naylor, L.H., Whyte, G.P., Shave, R.E., Oxborough, D. and Green, D.J. (2010) 'Diastolic function in healthy humans: non-invasive assessment and the impact of acute and chronic exercise', European Journal of Applied Physiology, 108(1), pp.1-14
Collections
- Sport Research Groups [620]
Related items
Showing items related by title, author, subject and abstract.
-
A depression in left ventricular diastolic filling following prolonged strenuous exercise is associated with changes in left atrial mechanics
Oxborough, David; Whyte, Greg; Wilson, Matthew; O'Hanlon, Rory; Birch, Karen; Shave, Rob; Smith, Gillian; Godfrey, Richard; Prasad, Sanjay; George, Keith (Elsevier, 2010)Background Standard marathon running can result in a depression of left ventricular (LV) diastolic function during early recovery. Left atrial (LA) mechanics are integral in maintaining an early diastolic pressure ... -
Impaired myocardial function does not explain reduced left ventricular filling and stroke volume at rest or during exercise at high altitude
Stembridge, Mike; Ainslie, Philip; Hughes, Michael G.; Stöhr, Eric J.; Cotter, James D.; Tymko, Michael M.; Day, Trevor A.; Bakker, Akke; Shave, Rob (American Physiological Society, 2015-11-15)Impaired myocardial systolic contraction and diastolic relaxation have been suggested as possible mechanisms contributing to the decreased stroke volume (SV) observed at high altitude (HA). To determine whether intrinsic ... -
A comparison of Doppler, tissue Doppler imaging, and strain rate imaging in the assessment of postexercise left ventricular function
Shave, Rob; George, Keith; Whyte, Greg; Middleton, Natalie; Hart, Emma; Artis, Nigel; Oxborough, David (NRC Research Press, 2009)Left ventricular (LV) function is characterized by contraction in the longitudinal, radial, and circumferential planes. Previous studies of postexercise changes in LV function have assessed global indices of LV function. ...