| dc.contributor.author | Chauhan, A. | |
| dc.contributor.author | Sequeria, A. | |
| dc.contributor.author | Manderson, C. | |
| dc.contributor.author | Maddocks, M. | |
| dc.contributor.author | Wasley, David | |
| dc.contributor.author | Wilcock, A. | |
| dc.date.accessioned | 2013-07-10T09:12:35Z | |
| dc.date.available | 2013-07-10T09:12:35Z | |
| dc.date.issued | 2012 | |
| dc.identifier.citation | Chauhan, A., Sequeria, A., Manderson, C., Maddocks, M., Wasley, D. and Wilcock, A. (2012) 'Exploring autonomic nervous system dysfunction in patients with cancer cachexia: a pilot study', Autonomic Neuroscience, 166 (1), pp.93-95 | en_US |
| dc.identifier.issn | 1566-0702 | |
| dc.identifier.uri | http://hdl.handle.net/10369/4444 | |
| dc.description.abstract | Introduction
Abnormalities of the autonomic nervous system (ANS) have been associated with cachexia.
Methods
In nine cancer patients who had lost weight and nine age-matched healthy volunteers heart rate variability (HRV) components were determined, together with serum cortisol and urinary catecholamines/metanephrines.
Results
Compared to volunteers, patients exhibited a global reduction in HRV parameters, significantly so for high frequency, low frequency and total power (median values ms2 103 vs. 313, 62 vs. 148 and 316 vs. 736 respectively, P < 0.05). Biochemical values did not differ.
Conclusion
Our results suggest the presence of ANS dysfunction in patients with cancer cachexia, with reduction in both sympathetic and parasympathetic components. | |
| dc.language.iso | en | en_US |
| dc.relation.ispartofseries | Autonomic Neuroscience: Basic and Clinical; | |
| dc.subject | Cancer cachexia | en_US |
| dc.subject | Heart rate variability | en_US |
| dc.subject | Autonomic nervous system | en_US |
| dc.title | Exploring autonomic nervous system dysfunction in patients with cancer cachexia: a pilot study | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | http://dx.doi.org/10.1016/j.autneu.2011.09.006 | |
