Can vascular structure and function change by altering brachial artery blood flow using an external pressure cuff pulsation technique
Cardiff Metropolitan University
MetadataShow full item record
Purpose: There are numerous contr ibutors that cause changes to vascular structure and funct ion, most revolve around exercise. A major determinant of vascular change is shear stress, which is inf luenced by the amount of force placed on the artery. An external cuf f pulsat ion intervent ion wi l l at tempt to regulate blood f low and al ter shear st ress; this wi l l clar ify whether blood f low changes acute vascular structure and funct ion. I f proven, addi t ional rehabi l itat ion processes for individuals suf fer ing from angina or vascular damage may be benef ited. Method: Physical ly act ive males volunteered as part icipants. A non - invasive method of Flow-Mediated Di lat ion was used to assess the vascular adaptat ions before and af ter a 5-minute cuf f pulsat ion intervent ion at 60% of their systol ic blood pressure. Resul ts: A signi f icant dif ference was found when compar ing t ime to peak arter ial di lat ion (TTPAD) before and af ter the intervent ion (86.7 + 16.0 sec; 107.95 + 36.3 sec, respect ful ly). There were sl ight changes found in other var iables such as delta diameter, shear rate and arter ial diameter, however, no signi f icant di f ference was ident if ied. Moreover, blood pressure remained relat ively constant throughout the whole procedure. Conclusion: The resul ts show that a cuf f pulsat ion intervent ion increases TTPAD signi f icant ly, but has l i t t le acute ef fect on vascular response in other var iables. This may be due to the extent that the cuf f st resses the artery. In addi t ion, the avai labi l i ty of Ni tr ic Oxide, the mediator of vascular di lat ion may also play a role in the vasodi lat ion of an ar tery, as the st imulus to release Ni t r ic Oxide is too l it t le to make an ef fect and causes an increase TTPAD. Greater external pressure may therefore resul t in signi f icant ly di f ferent acute adaptat ions.
Showing items related by title, author, subject and abstract.
The influence of habitual exercise on central haemodynamics and peripheral blood pressure regulation in normotensive middle-aged men Wakeham, Denis (Cardiff Metropolitan University, 2020)Central (aortic) haemodynamics change markedly with age, as aortic stiffness and systolic pressure augmentation increase thereby elevating aortic blood pressure. Furthermore, the autonomic regulation of vascular sympathetic ...
Hypoxia, not pulmonary vascular pressure induces blood flow through intrapulmonary arteriovenous anastomoses Tremblay, Joshua; Lovering, Andrew T.; Ainslie, Philip; Stembridge, Mike; Burgess, Keith R.; Bakker, Akke; Donnelly, Joseph; Lucas, Samuel J.E.; Lewis, Nia C. S.; Dominelli, Paolo B.; Henderson, William R.; Dominelli, Giulio S.; Sheel, A. William; Foster, Glen (The Physiological Society, 2014-12-23)Blood flow through intrapulmonary arteriovenous anastomoses (IPAVA) is increased with exposure to acute hypoxia and has been associated with pulmonary artery systolic pressure (PASP). We aimed to determine the direct ...
Matrix Metalloproteinase-9 and Augmentation Index are reduced with an 8-week green-exercise walking programme McDonnell, Barry; Thompson, Jane. E.S; Webb, Richard; Hewlett, Paul; Llewellyn, David (OMICS International, 2013)Objectives: MMP-9 is involved in degrading the Extracellular Matrix (ECM); specifically elastin, which provides elasticity to the arterial wall. Elastin degradation and restructuring of the ECM results in increased vascular ...